EFFECT OF ANGIOTENSIN II ON MATURATION OF OOCYTES OF COWS IN VITRO



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Abstract

Physiological function of angiotensin II, in particular, the role of angiotensin II in the maturation of cows' eggs is not sufficiently evaluated. The purpose of this study was to evaluate the effect of different concentrations of angiotensin II on the maturation of the nuclei of cows' eggs in vitro in serum-free medium aMEM with hormonal additives or without them. In the first series of experiments, the cows' eggs matured in vitro in a medium containing hormonal additives with three different concentrations of angiotensin II (10-11, 10-9, 10-7 М). The criterion of successful maturation was the ability of the eggs to reach the stage of metaphase II. Our results demonstrate that angiotensin II in concentrations of 10-11, 10-9, 10-7 М does not affect the maturation of the egg nucleus in vitro if the maturation medium contained hormonal additives (57,1% eggs with the first polar body in the control vs 64,6% in the experiment; 60,8% vs 58,6%; 65,2% vs 66,7%, respectively). In the second series of experiments, the eggs were cultured in a medium without hormonal additives, where angiotensin II was added to a concentration of 10-7 М. Angiotensin II at a concentration of 10-7М significantly suppressed the release of the first polar body (43,6% in the control vs 29,3% in the experiment, P<0,05). This allows us to make a preliminary conclusion that the hormones cancel the inhibitory effect of angiotensin II on the maturation of the nucleus of cows' eggs in vitro. Further research is needed on the mechanisms by which angiotensin II regulates the maturation of cows' eggs. The question of angiotensin II as a possible component of culture media remains open.

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About the authors

I. G Smetanina

All-Russian Research Institute of Physiology, Biochemistry, and Nutrition of Animals - Branch of the L.K. Ernst Federal Science Center for Animal Husbandry

Email: sme.irina2011@yandex.ru

L. V Tatarinova

All-Russian Research Institute of Physiology, Biochemistry, and Nutrition of Animals - Branch of the L.K. Ernst Federal Science Center for Animal Husbandry

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