Astrocytes and their participation in the mechanisms of therapeutic action of MSC in ischemic brain injury

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This review summarizes data on the role of astrocytes in the normal brain function and disease. After ischemic injury astroglia participates in the processes of endogenous repair and helps the surviving nerve cells to regain their lost functions. The response of astrocytes to ischemia depends on the severity of the disease and can determine its further development. To date, cellular therapy is a promising strategy in the treatment of post-stroke states. Numerous studies have shown the positive effect of mesenchymal stem cells (MSC) on functional recovery after ischemic stroke. The main effect is probably associated to the ability of MSC to enhance the endogenous restoration potential of nerve tissue. Recent experimental data have demonstrated that a special role in the therapeutic effects of cell therapy belongs to astroglial cells. Further study of the interaction of MSC and astrocytes will help in the search for new approaches in the treatment of the ischemic injury consequences.

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About the authors

Y. A Kalinina

“Trans-Technologies", Ltd


E. G Gilerovich

Institution of Experimental Medicine

D. E Korzhevskii

Institution of Experimental Medicine


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