Association of TNF, MMP9, CYBA polymorphism with subclinical arterial wall changes and cardiovascular diseases risk factors



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Abstract

Chronic inflammation and oxidative stress play key role in arterial wall changes and cardiovascular diseases. There is limited evidence on influence of genotypes, which are correlated with dironic inflammation and oxidative stress at arterial wall changes (pulse wave velocity, carotid artery intima-media thickness, endothelium-dependent vasodilation, presence of atherosclerotic plaques) and risk factors of cardiovascular diseases. We examined association of TNF-238G>A polymorphism, MMP9 -1562C>T polymorphism, CYBA c.214Т>С polymorphism with arterial wall changes and risk factors of cardiovascular diseases in 160 healthy people of different ages. GG genotype of TNF -238G>A polymorphism was associated with lower levels of aldosterone (p=0,021), higher levels of glycated haemoglobin (p=0,02) and insulin-like growth factor (p=0,032). СТ genotype of MMP9 -1562C>T polymorphism was associated with most commonly found obesity (p=0,05). CC and TC genotypes of CYBA c.214Т>С polymorphism were associated with shorter leucocyte telomere length (p=0,011). There wasn't found any association of TNF, MMP9, CYBA polymorphism with arterial wall changes. Association was found between TNF -238G>A polymorphism and MMP9 -1562C>T polymorphism with metabolic parameters, CYBA c.214Т>С polymorphism with leucocyte telomere length.

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About the authors

A. A Akopyan

Medical Scientific and Educational Center of M.V. Lomonosov Moscow State University; Russian Clinical and Research Center of Gerontology N.I. Pirogov Russian National Research Medical University

Email: a.alexandrova18@gmail.com
Moscow, Russia

K. I Kirillova

Medical Scientific and Educational Center of M.V. Lomonosov Moscow State University

Email: a.alexandrova18@gmail.com
Moscow, Russia

I. D Strazhesko

Russian Clinical and Research Center of Gerontology N.I. Pirogov Russian National Research Medical University; Russian Clinical and Research Center of Gerontology N.I. Pirogov Russian National Research Medical University

Email: a.alexandrova18@gmail.com
Moscow, Russia

L. M Samokhodskaya

Medical Scientific and Educational Center of M.V. Lomonosov Moscow State University

Email: a.alexandrova18@gmail.com
Moscow, Russia

S. L Leonov

I.I. Polzunov Altai State Technical University

Email: a.alexandrova18@gmail.com
Barnaul, Russia

E. M Gelfand

I.I. Polzunov Altai State Technical University

Email: a.alexandrova18@gmail.com
Barnaul, Russia

A. G Sorokina

Medical Scientific and Educational Center of M.V. Lomonosov Moscow State University

Email: a.alexandrova18@gmail.com
Moscow, Russia

I. A Orlova

Medical Scientific and Educational Center of M.V. Lomonosov Moscow State University

Email: a.alexandrova18@gmail.com
Moscow, Russia

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