Osteogenesis in epitelial tumors on the example of a pilomatricomas



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Abstract

Heterotopic osteogenesis (HO) is the process of formation of typical bone tissue in a place in the body where this tissue normally does not develop. HO can be the outcome of many pathological processes, for example, necrosis, the organization of hematomas and primary tuberculous affect, and also develop in tumors of various histogenesis. This may be an example of the mutual induction of tissue development in an adult organism. Pilomatricoma (epithelioma of Malherbe) is a rare benign tumor, accounting for 0,2% of all skin neoplasms, developing from the hair follicle epithelium. In rare cases, foci of HO can be detected in the tumor structure. 43 cases pilomatricomas were analyzed by, in 3 (7%) of which bone tissue was detected. Histological and immunohistochemical studies and clinical morphological analysis were performed.

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About the authors

R. V Deev

Human Stem Cell Institute; I.I. Mechnikov North-Western State Medical University

Email: romdey@gmail.com

I. L Plaksa

Human Stem Cell Institute; Moscow City Oncology Hospital № 62

Email: romdey@gmail.com

A. V Baranich

I.P. Pavlov Ryazan State Medical University

Email: romdey@gmail.com

E. V Shcherbakova

I.I. Mechnikov North-Western State Medical University

Email: romdey@gmail.com

I. I Vinogradov

I.P. Pavlov Ryazan State Medical University; Ryazan Regional Clinical Oncology Center

Email: romdey@gmail.com

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