Role of the immune system in COVID-19 pathomorphogenesis



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Abstract

The new coronavirus infection is a highly contagious infection caused by the SARS-CoV-2 virus that has become a global public health problem. The pathogenesis of this virus has not yet been clearly understood, the principles of hyperinflammatory immune response in critically ill patients, which leads to acute respiratory distress syndrome and multiple organ failure, innate and adaptive immune responses in the process of structuring the data under study. The interaction of the virus and a macroorganism includes 4 stages: infection, dissemination, cytokine storm, pulmonary fibrosis. This review analyzes the predictors of infection, its possible pathogenesis, the immune response of the macroorganism, as well as the histological characteristics of damage to immune organs; shows receptors for SARS-CoV-2 (ACE2, TMPRSS2) in some organs.

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About the authors

E. D Studenikina

I.I. Mechnikov North-Western State Medical University

A. I Ogorelysheva

I.I. Mechnikov North-Western State Medical University

Ya. S Ruzov

I.I. Mechnikov North-Western State Medical University

I. R Khabibullin

I.I. Mechnikov North-Western State Medical University

I. Z Samorukova

I.I. Mechnikov North-Western State Medical University

O. N Chernova

I.I. Mechnikov North-Western State Medical University

Z. P Asaulenko

City Hospital № 40 of Kurortny District of Saint-Petersburg

M. O Mavlikeev

I.I. Mechnikov North-Western State Medical University

I. N Budnicova

I.I. Mechnikov North-Western State Medical University

V. I Nikolaev

I.I. Mechnikov North-Western State Medical University

S. A Vinnichuk

I.I. Mechnikov North-Western State Medical University

R. V Deev

I.I. Mechnikov North-Western State Medical University

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