Influence of Autologous Connective Tissue (Stromal) Bone Marrow Cells (SBMC)Upon Delayed-Forming Distraction Regenerates in Children
- Authors: Mironov, SP1, Omelyanenko, NP1, Kzhevnikova OV1, Ilina, VK1, Ivanov, AV1, Karpov IN1
-
Affiliations:
- FSI «Central Scientific Research Institute of Traumatology and Orthopaedics named after N.N. Priorov»Ministry of Health and Social Development of Russian Federation
- Issue: Vol 6, No 2 (2011)
- Pages: 104-112
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121682
- DOI: https://doi.org/10.23868/gc121682
- ID: 121682
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Abstract
marrow cells use for the stimulation of distraction bone
regenerates in 8 children aged from 3.7 to 16.0 years with
congenital lower extremities length discrepancy (main group)
are compared with those achieved for 24 children aged
2.5-14.0 with similar pathology who were treated without
application of cell technology (control group). Treatment
results are indicative of marked stimulating effect of cell
therapy upon the formation and maturation of distraction
bone regenerates after surgical correction of lower
extremities length discrepancy. In the main group duration
of treatment reduced to 4,5-6,5 months versus 7,5-11
months in the control group. Subsequently with growth of
children the elongated limb segments in children from the
main group showed less delay in development as compared
with elongated limb segments in patients from the control
group. It is obvious that use of SBMC has exerted stimulating
effect upon the growth of the whole segment of the operated
extremity approximating the rates of its development the
physiological ones.
Reduction of treatment duration enabled to avoid potential
complications related to prolonged extremity fixation in
distraction apparatus and to perform rehabilitation at earlier
terms than in patients from the control group that led to the
improvement of anatomical and functional results.
About the authors
S P Mironov,
FSI «Central Scientific Research Institute of Traumatology and Orthopaedics named after N.N. Priorov»Ministry of Health and Social Development of Russian FederationFSI «Central Scientific Research Institute of Traumatology and Orthopaedics named after N.N. Priorov»Ministry of Health and Social Development of Russian Federation
N P Omelyanenko,
FSI «Central Scientific Research Institute of Traumatology and Orthopaedics named after N.N. Priorov»Ministry of Health and Social Development of Russian FederationFSI «Central Scientific Research Institute of Traumatology and Orthopaedics named after N.N. Priorov»Ministry of Health and Social Development of Russian Federation
O V Kzhevnikova
FSI «Central Scientific Research Institute of Traumatology and Orthopaedics named after N.N. Priorov»Ministry of Health and Social Development of Russian FederationFSI «Central Scientific Research Institute of Traumatology and Orthopaedics named after N.N. Priorov»Ministry of Health and Social Development of Russian Federation
V K Ilina,
FSI «Central Scientific Research Institute of Traumatology and Orthopaedics named after N.N. Priorov»Ministry of Health and Social Development of Russian FederationFSI «Central Scientific Research Institute of Traumatology and Orthopaedics named after N.N. Priorov»Ministry of Health and Social Development of Russian Federation
A V Ivanov,
FSI «Central Scientific Research Institute of Traumatology and Orthopaedics named after N.N. Priorov»Ministry of Health and Social Development of Russian FederationFSI «Central Scientific Research Institute of Traumatology and Orthopaedics named after N.N. Priorov»Ministry of Health and Social Development of Russian Federation
I N Karpov
FSI «Central Scientific Research Institute of Traumatology and Orthopaedics named after N.N. Priorov»Ministry of Health and Social Development of Russian FederationFSI «Central Scientific Research Institute of Traumatology and Orthopaedics named after N.N. Priorov»Ministry of Health and Social Development of Russian Federation
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