Tsirkuliruyushchie gemopoeticheskie i endotelial'nyepredshestvenniki v perifericheskoy krovi patsientovs cherepno-mozgovoy travmoy



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Abstract

В настоящей работе исследована мобилизация ге-
мопоэтических стволовых/прогениторных клеток (ГСК)
и эндотелиальных предшественников (ЭП) у больных с
черепно-мозговой травмой (ЧМТ). В первые 24-48 ч по-
сле ЧМТ выявлено достоверное возрастание абсолютного
количества циркулирующих CD34+CD45+ГСК, а также от-
носительного и абсолютного количества CD34+CD144+ЭП.
Эффективность мобилизации ГСК была достоверно выше
в группе больных до 40 лет, и относительное содержание
CD45+CD34+ клеток находилось в обратной зависимости
от возраста пациентов (r = -0,54, р = 0,039). Возрас-
тание CD45+CD34+ГСК и CD34+CD144+ЭП регистриро-
валось как у больных с легкой, так и среднетяжелой/тя-
желой ЧМТ и не зависело от уровня сознания по шкале
комы Глазго (ШКГ). Однако у больных с отсутствием воз-
растания CD45+CD34+ клеток частота неблагоприятных
исходов (1-3 балла по шкале исходов Глазго; ШИГ) была
достоверно выше, чем в подгруппе больных с повышенным
количеством ГСК (p = 0,047). Выявлена также значимая
взаимосвязь ранних ЭП, не экспрессирующих VE-кадгерин
(CD3-CD34+CD144-ЭП), с тяжестью/исходом ЧМТ (r = 0,6;
p = 0,017 и r = 0,53; p = 0,035, соответственно). Таким
образом, интенсивность мобилизации ГСК и ЭП у больных
ЧМТ может быть использована в качестве прогностического
фактора, свидетельствующего о репаративном потенциале
костномозговых предшественников.

About the authors

V A Chernykh

Institute of travmatology and orthopedy, Novosibirsk

Institute of travmatology and orthopedy, Novosibirsk

N V Pronkina

Institute of clinical immunology SB RAMS, Novosibirsk

Institute of clinical immunology SB RAMS, Novosibirsk

V V Stupak

Institute of travmatology and orthopedy, Novosibirsk

Institute of travmatology and orthopedy, Novosibirsk

V V Fonin

City clinical hospital №1, Novosibirsk

City clinical hospital №1, Novosibirsk

P E Shishlov

City clinical hospital №1, Novosibirsk

City clinical hospital №1, Novosibirsk

E Ya Shevela

O Yu Leplina

Institute of clinical immunology SB RAMS, Novosibirsk

Institute of clinical immunology SB RAMS, Novosibirsk

E R Chernykh

Institute of clinical immunology SB RAMS, Novosibirsk

Institute of clinical immunology SB RAMS, Novosibirsk

A A Ostanin

Institute of clinical immunology SB RAMS, Novosibirsk

Institute of clinical immunology SB RAMS, Novosibirsk

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