Autophagy induction in peripheral blood T-lymphocytes of atopic asthma patients
- Authors: Skibo YV1, Ponomareva AA2, Reshetnikova ID3, Abramova ZI1
-
Affiliations:
- Kazan (Volga Region) Federal University, Kazan
- Kazan Institute of Biochemistry and Biophysics of RAS, Kazan
- Kazan SRI of Epidemiology and Microbiology, Kazan
- Issue: Vol 7, No 3 (2012)
- Pages: 146-150
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121650
- DOI: https://doi.org/10.23868/gc121650
- ID: 121650
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Abstract
Autophagy is a fundamental process that ensures
the regulation of T-cell homeostasis. In case of apoptosis
induction disruption in the cell it could be single mechanism of
the cell death. Previously was shown inhibition of lymphocyte
apoptosis in patients with bronchial asthma, so the main study
of this work has focused on the study development process
of autophagy in T-lymphocytes of patients with bronchial
asthma. The article presents the main morphological changes
in cells associated with activation of autophagy (formation
autophagosome). In addition to morphological changes in
lymphocytes, we have shown the expression of autophagy
marker protein (LC3B). We found that in T-lymphocytes of
patients with severe asthma are simultaneous activation of
both autophagy and apoptosis, and autophagy is a stimulus
to cell death.
the regulation of T-cell homeostasis. In case of apoptosis
induction disruption in the cell it could be single mechanism of
the cell death. Previously was shown inhibition of lymphocyte
apoptosis in patients with bronchial asthma, so the main study
of this work has focused on the study development process
of autophagy in T-lymphocytes of patients with bronchial
asthma. The article presents the main morphological changes
in cells associated with activation of autophagy (formation
autophagosome). In addition to morphological changes in
lymphocytes, we have shown the expression of autophagy
marker protein (LC3B). We found that in T-lymphocytes of
patients with severe asthma are simultaneous activation of
both autophagy and apoptosis, and autophagy is a stimulus
to cell death.
Keywords
About the authors
Y V Skibo
Kazan (Volga Region) Federal University, KazanKazan (Volga Region) Federal University, Kazan
A A Ponomareva
Kazan Institute of Biochemistry and Biophysics of RAS, KazanKazan Institute of Biochemistry and Biophysics of RAS, Kazan
I D Reshetnikova
Kazan SRI of Epidemiology and Microbiology, KazanKazan SRI of Epidemiology and Microbiology, Kazan
Z I Abramova
Kazan (Volga Region) Federal University, KazanKazan (Volga Region) Federal University, Kazan
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