Autophagy induction in peripheral blood T-lymphocytes of atopic asthma patients

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Autophagy is a fundamental process that ensures
the regulation of T-cell homeostasis. In case of apoptosis
induction disruption in the cell it could be single mechanism of
the cell death. Previously was shown inhibition of lymphocyte
apoptosis in patients with bronchial asthma, so the main study
of this work has focused on the study development process
of autophagy in T-lymphocytes of patients with bronchial
asthma. The article presents the main morphological changes
in cells associated with activation of autophagy (formation
autophagosome). In addition to morphological changes in
lymphocytes, we have shown the expression of autophagy
marker protein (LC3B). We found that in T-lymphocytes of
patients with severe asthma are simultaneous activation of
both autophagy and apoptosis, and autophagy is a stimulus
to cell death.

About the authors

Y V Skibo

Kazan (Volga Region) Federal University, Kazan

Kazan (Volga Region) Federal University, Kazan

A A Ponomareva

Kazan Institute of Biochemistry and Biophysics of RAS, Kazan

Kazan Institute of Biochemistry and Biophysics of RAS, Kazan

I D Reshetnikova

Kazan SRI of Epidemiology and Microbiology, Kazan

Kazan SRI of Epidemiology and Microbiology, Kazan

Z I Abramova

Kazan (Volga Region) Federal University, Kazan

Kazan (Volga Region) Federal University, Kazan


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