Biosafety model of adenovirus infection: effects of bacterial proteases for infection of human cells in vitro
- Authors: Martinova EV1, Danilova YV2, Anohin VA1, Khaiboullina SF3, Rizvanov AA2, Sharipova MR2
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Affiliations:
- Кazan State Medical University, Kazan
- Кazan (Volga region) Federal University, Kazan
- Whittemore Peterson Institute, Reno, USA
- Issue: Vol 7, No 3 (2012)
- Pages: 105-107
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121630
- DOI: https://doi.org/10.23868/gc121630
- ID: 121630
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Abstract
active compounds, the model of adenovirus infection on the
basis of cell cultures of human HEK293A and recombinant
adenovirus Ad-EGFP, expressing green fluorescent protein
EGFP. Adenoviruses have a capsid size of 70-90 nm and are
able to infect dividing and nondividing cells in vitro and in vivo.
Recombinant adenoviruses are the replicative defect in the
cells of humans and animals. The developed model allowed
us to determine the effect of bacterial proteases in the
infected cell cultures with adenovirus. This model can also
be used for screening drugs with potential protivivovirusnoy
activity.
About the authors
E V Martinova
Кazan State Medical University, KazanКazan State Medical University, Kazan
Y V Danilova
Кazan (Volga region) Federal University, KazanКazan (Volga region) Federal University, Kazan
V A Anohin
Кazan State Medical University, KazanКazan State Medical University, Kazan
S F Khaiboullina
Whittemore Peterson Institute, Reno, USAWhittemore Peterson Institute, Reno, USA
A A Rizvanov
Кazan (Volga region) Federal University, KazanКazan (Volga region) Federal University, Kazan
M R Sharipova
Кazan (Volga region) Federal University, KazanКazan (Volga region) Federal University, Kazan
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