Histogenesis of solid-pseudopapillary tumor of a pancreas

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Abstract

Solid-pseudopapillary tumor (SPPO) is a rare tumor of a pancreas with unknown histogenesis. In this regards some theories about its development are discussed including genesis from so called cancer stem cells, which can be derivative of embryonic ovaries primordiums. We studied 11 SPPO and 5 ovarian granulosa cell tumors (GCT) adult type by electron microscopy. A comparative ultrastructural study identified similar features in GCT and SPPO: the presence of two cells types, one of which with characteristic nuclei with deep invaginations nukleolemmy as longitudinal furrows, intercellular contacts in the form of desmosomes, in the tissues quite large number of capillaries in the active state were detected. Among all ovarian tumors developing from cells of sex cord stroma SPPO is the most close to GCT. They are related not only due to morphological similarity, but the biological potential, the clinical course and disease prognosis. Our studies confirm the theory of embryonic migration of ovaries primordiums cells with their subsequent contribution to SPPO histogenesis.

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O. V Paklina

A.I. Burnazyan Federal Medical Biophysical Center of FMBA, Russia

E. N Gordienko

A.V. Vishnevsky Research Institute of Surgery, Moscow

I. A Chekmareva

A.V. Vishnevsky Research Institute of Surgery, Moscow

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