The First experience of quantitative evaluation of therapeutic angiogenesis results
- Authors: Katelnitskiy I.I1, Katelnitskiy I.L1, Alexeeva G.A1
-
Affiliations:
- Rostov State Medical University, Rostov-on-Don
- Issue: Vol 7, No 4 (2012)
- Pages: 83-85
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121582
- DOI: https://doi.org/10.23868/gc121582
Cite item
Full Text
Abstract
The goal of research is objective evaluation of effectiveness of therapeutic angiogenesis in patients with critical lower limb ischemia of the atherosclerotic etiology. It was shown that angiogenesis induction by drug Neovasculgen was manifested by good clinical effect in the nearest period and that was confirmed by growth of tissue blood flow according to laser Doppler flowmetry. Use of technetium-pertehnetate- macroaggregates angioscintigraphy with intra-arterial administration of the drug allowed to assess objectively the increase of blood flow to the increased volume of the vascular bed.
Full Text
About the authors
I. I Katelnitskiy
Rostov State Medical University, Rostov-on-Don
IG. L Katelnitskiy
Rostov State Medical University, Rostov-on-Don
G. A Alexeeva
Rostov State Medical University, Rostov-on-Don
References
- Покровский А.В., Москаленко Ю.Д., Кияшко В.А. Реконструктивные операции при тяжелой ишемии нижних конечностей. Хирургия 2007; 11: 20-7.
- Покровский А.В. Клиническая ангиология: руководство для врачей. М.: Медицина; 2004.
- Kosch M., Hausberg M., Westermann G. et al. Alteration in calcium and magnesium content of red cell membranes in patient with primary hypertension. Am. J. Hypertension 2000; 3: 254-8.
- Dominguez L.J., Barbagallo M., Sowers J.R. et al. Magnesium responsiveness to insulin and insulin-like growth factor I in erythrocytes from normotensive and hypertensive subjects. J. Clin. Endocrinol. Metab. 1998; 12: 4402-7.
- Handengue A.L., Del-Pino M., Simon A. et al. Erythrocyte disaggregation shear stress, sialic acid, and cell aging in humans. Hypertension 1998; 2: 324-30.
- McDonald W., Blake M.P. Periostitis and localized myositis in polyarteriitis nodosa. Clin. Nucl. Med. 2004; 29(11): 547-9.
- Аверьянов М.Ю., Измайлов С.Г. Тромбозы и эмболии магистральных артерий. Нижний Новгород; 2007.
- Свирщевский Е.Б., Чазова Т.Е. Микроциркуляция в нижних конечностях при диабете. Вестник РАМН 2002; 5: 45-51.
- Soyer H., Ulsu I. A patient with peripheral arterial stenosis diagnosed with low extremity perfusion scintigraphy. Clin. Nucl. Med. 2007; 32(6): 458-9.
- Лишмакова Ю.Б., Чернова В.И. Радионуклидная диагностика для практических врачей. Томск; 2004.
- Ishiyama K., Tomura N., Okada K. et al. Evaluating benign and malignant musculoskeletal lesions with radionuclide angiography and SPECT using Tc-99m-MIBb. Clin. Nucl. Med. 2005; 30(9): 598-603.
