The key stages of iPSCs differentiation into neuronal and glial cells

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Abstract

Brain's neurodegenerative diseases are one of the most actual problems of neurology and neurobiology. The lack of the modern methods of treating this diseases stimulates to develop new effective approaches based on neuronal and glial cells, which requires studying the signaling mechanisms of neural differentiation. This review considers the key mechanisms and substances involved in the formation of the neuroepithelium in vivo, as well as for obtaining the neural stem cells from iPSCs and its further differentiation in various types of neuronal and glial cells in vitro.

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About the authors

D. I Salikhova

Research Center for Medical Genetics; Research Institute of Human Morphology

Email: diana_salikhova@bk.ru

IA. Fedyunina

Research Center for Medical Genetics

T. B Bukharova

Research Center for Medical Genetics

D. V Goldshtein

Research Center for Medical Genetics

S. L Kiselev

Research Center for Medical Genetics; Vavilov Institute of General Genetics, Russian Academy of Sciences

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