Role of the different signal transduction systems on intervertebral disk degeneration



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Abstract

The review systematized the modern data reported about signaling system role in the intervertebral disk degeneration, that is one of the main reasons for back pain and patients' disability as a result. We represented current data revealing molecular-cell mechanisms of disk degeneration. The experimental data analysis of the cytokines and biologic active molecules influencing on the intervertebral disk degenerative diseases development is presented. We denoted actual, still remaining unsolved questions concerning treatment of the diseases that required further experimental studies with opportunity for clinical translation.

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About the authors

V. A Byvaltsev

Irkutsk State Medical University; Irkutsk Railway Clinical Hospital; Scientific Center of Reconstructive and Restorative Surgery; Irkutsk State Medical Academy of Postgraduate Education

Email: byval75_vadim@yandex.ru

N. E Garashchenko

Irkutsk State Medical University; Irkutsk National Research Technical University

I. A Stepanov

Irkutsk State Medical University

N. T Aldiyarova

Republican Center of Health Development, Astana

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