Multipotent stromal cells in the treatment of acute liver failure after extended hepatectomy in the experiment


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Abstract

Resection of the liver is the main method of treatment in primary and metastatic liver tumors. Frequent complication after extended hepatectomy is acute liver failure, which occurs in 33.83% of cases and may lead to death. The aim of this study is to determine the therapeutic potential of multipotent mesenchymal stromal cells in the treatment of acute liver failure after extended hepatectomy in animal models (rats). The liver mass (before and after 70% hepatectomy), synthetic function of the liver, the level of liver enzymes were measured. The results showed that transplantation of 2.5 mil. of multipotent mesenchymal stromal cells of bone marrow into the inferior vena cava improves liver function and decrease the level of liver enzymes. We observed better recovery of liver mass, and liver functional test (total protein, albumin, alkaline phosphatase, INR, APTT, direct bilirubin) in the experimental group. Thus, multipotent mesenchymal stromal cells have therapeutic effect in treatment of acute liver failure after extended hepatectomy in the experiment. However, more research is needed to understand the mechanisms of therapeutic action of these cells after extended hepatectomy.

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About the authors

V. S Rudakov

Burnasyan Federal Medical Biophysical Center, Federal Medical Biological Agency

Moscow, Russia

S. E Voskanyan

Burnasyan Federal Medical Biophysical Center, Federal Medical Biological Agency, Moscow, Russia

Moscow, Russia

I. I Eremin

Central Clinical Hospital with Polyclinics of Administration of President of the Russian Federation

Moscow, Russia

I. E Onnitsev

S.M. Kirov Military Medical Academy

Saint-Petersburg, Russia

R. V Deev

Human Stem Cells Institute; I.P. Pavlov Ryazan State Medical University

Ryazan, Moscow Russia

E. V Naydenov

Burnasyan Federal Medical Biophysical Center, Federal Medical Biological Agency

Ryazan, Russia

P. S Eremin

Central Clinical Hospital with Polyclinics of Administration of President of the Russian Federation

Ryazan, Russia

1 1 A.A. Y.A. Zhgutov

Burnasyan Federal Medical Biophysical Center, Federal Medical Biological Agency

Moscow, Russia

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