Editing of DNA epigenetic modifications



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Abstract

Геномное редактирование в последние годы прочно вошло в арсенал методов молекулярной и клеточной биологии. Однако у высших эукариот огромную роль в формировании фенотипа клеток и организма в целом играет также состояние эпигенома - системы ковалентных модификаций ДНК и связанных с ней белков, регулирующих экспрессию генов. Методы редактирования эпигенома только начинают появляться, и в сочетании с технологиями геномного редактирования должны обеспечить более надежный контроль состояния изменяемых клеток. В обзоре освещены механизмы метилирования и активного деметилирования ДНК в клетках высших организмов и способы их применения для направленного изменения состояния эпигенома.

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About the authors

I. R Grin

Institute of Chemical Biology and Fundamental Medicine, the Siberian Branch of the Russian Academy of Sciences; National Research University Novosibirsk State University

Novosibirsk, Russia

D. V Petrova

Institute of Chemical Biology and Fundamental Medicine, the Siberian Branch of the Russian Academy of Sciences; National Research University Novosibirsk State University

Novosibirsk, Russia

D. O Zharkov

Institute of Chemical Biology and Fundamental Medicine, the Siberian Branch of the Russian Academy of Sciences; National Research University Novosibirsk State University

Novosibirsk, Russia

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