Description of methods for the detection of Helicobacter pylori in children with chronic gastroduodenal pathology

Frequent detection of Helicobacter pylori infection among both adult and child population, as well as its relationship with the development of chronic gastroduodenal pathology field justified the need to search for sensitive and accurate diagnostic methods. This has stimulated the emergence of a variety of different methods for detecting Helicobacter pylori, which created for clinicians and specialists laboratory diagnosis difficulties in choosing the adequate and reliable ways to identify. A comparative analysis of methods for diagnosis of Helicobacter pylori infection in 151 children with chronic gastroduodenal pathology field, including 23 patients with duodenal ulcer, 97 patients with chronic gastroduodenitis and 31 conditionally healthy children of the same age. Breathing helic - test and polymerase chain reaction of gastric mucosa biopsies for the diagnosis of Helicobacter pylori infection have equally high sensitivity (94.8% and 93.6%) but low specificity (80.6% and 79.5%) and a high probability helicobakteriosis methods with negative results (19.4% and 18.4%).The analysis of the diagnostic value of the combination helic - test and polymerase chain reaction in the verification of Helicobacter pylori infection showed a higher sensitivity (98.3%) and specificity (93.5%) overall accuracy (96%) and the probability of a positive result helicobakteriosis (96.6%) and a low probability in a negative result (6.4%) methods. Therefore, for the primary diagnosis of Helicobacter pylori infection is better to use a combination of breathing helic -test and polymerase chain reaction biopsies gastric mucosa, reducing the proportion of false-positive and false-negative data, would increase the sensitivity and specificity of the methods.

Helicobacter pylori, diagnosis, Helicobacter pylori, cytological, polymerase chain reaction, respiratory helic - test, chronic gastroduodenitis, duodenal ulcer