The role of pancreatic stellate cells in pancreas regeneration in copper-deficient diet model in rats
- Authors: Abdulkhakova A.R1, Galyavieva A.R1, Abdulkhakov S.R1,2, Trondin A.A1, Pevnev G.O2, Titova M.A2, Gumerova A.A2, Kiassov A.P2
-
Affiliations:
- Kazan State Medical University
- Kazan (Volga region) Federal University
- Issue: Vol 9, No 3 (2014)
- Pages: 41-44
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/120291
- DOI: https://doi.org/10.23868/gc120291
- ID: 120291
Cite item
Abstract
Full Text

About the authors
A. R Abdulkhakova
Kazan State Medical University
A. R Galyavieva
Kazan State Medical University
S. R Abdulkhakov
Kazan State Medical University; Kazan (Volga region) Federal University
AA. A Trondin
Kazan State Medical University
G. O Pevnev
Kazan (Volga region) Federal University
MA. A Titova
Kazan (Volga region) Federal University
A. A Gumerova
Kazan (Volga region) Federal University
A. P Kiassov
Kazan (Volga region) Federal University
References
- Shen C.-N., Horb M.E., Slack J.M.W. et al. Transdifferentiation of pancreas to liver. Mech. Dev. 2003; 120: 107-16.
- Абдулхакова А.Р., Абдулхаков С.Р., Титова М. А. и др. Может ли поджелудочная железа быть источником развития гепатоцитов? Клеточная трансплантология и тканевая инженерия 2012; 3: 21-4.
- Scarpelli D.G., Rao M.S. Differentiation of regenerating pancreatic cells into hepatocyte-like cells. PNAS USA. 1981; 78: 2577-81.
- Rao S., Dwivedi R.S., Yeldandi A.V. et al. Role of periductal and ductular epithelial cells of the adult rat pancreas in pancreatic hepatocyte lineage. Am. J. Pathol. 1989; 134(5): 1069-85.
- Scarpelli D.G. Multipotent developmental capacity of cells in the adult animal. Lab. Invest. 1985; 52: 331-3.
- Reddy J.K., Rao M.S., Yeldandi A.V. et al. Pancreatic hepatocytes. An in vivo model for cell lineage in pancreas of adult rat. Dig. Dis. Sci. 1991; 36: 502-6.
- Rao M.S., Subbarao V., Reddy J.K. Induction of hepatocytes in the pancreas of copper-depleted rats following copper repletion. Cell Differ. 1986; 18: 109-17.
- Rao M.S., Dwivedi R.S., Subbarao V. et al. Almost total conversion of pancreas to liver in the adult rat: a reliable model to study transdifferentiation. Biochem. Biophys. Res. Commun. 1988; 156: 131-6.
- Apte M.V., Haber P.S., Applegate T.L. et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut. 1998; 43: 128-33.
- Bachem M.G., Schneider E., Gross H. et al. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 1998; 115: 421-32.
- Ничитайло М.Е., Кравченко Д.А., Медвецкий Е.Б. и др. Ингибирование активированных панкреатических звёздчатых клеток (витаминами А и Е) для предупреждения фиброза поджелудочной железы в модели хронического алкогольного панкреатита. Морфолопя. 2012; VI (2): 34-42.
- Erkan M., Adler G., Apte M.V. et al. StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut. 2012; 61(2): 172-8.
- Roskams T. Relationships among stellate cell activation, progenitor cells, and hepatic regeneration. Clin Liver Dis. 2008; 12: 853-60.
- Bachem M.G., Schunemann M., Ramadani M. et al. Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology 2005; 128: 907-21.
- Kloppel G., Detlefsen S., Feyerabend B. Fibrosis of the pancreas: the initial tissue damage and the resulting pattern. Virchows Arch. 2004; 445: 1-8.
- Phillips P.A., McCarroll J.A., Park S. et al. Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Gut. 2003; 52: 275-82.
- Vonlaufen A., Joshi S., Qu C. et al. Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Cancer Res. 2008; 68: 2085-93.
- Ammann R.W., Heitz P.U., Kloppel G. Course of alcoholic chronic pancreatitis: a prospective clinicomorphological long-term study. Gastroenterology 1996; 111: 224-31.
- Detlefsen S., Sipos B., Feyerabend B. et al. Fibrogenesis in alcoholic chronic pancreatitis: the role of tissue necrosis, macrophages, myofibroblasts and cytokines. Mod. Pathol. 2006; 19: 1019-26.
- Vonlaufen A., Phillips P.A., Xu Z. et al. Withdrawal of alcohol promotes regression while continued alcohol intake promotes persistence of LPS-induced pancreatic injury in alcohol-fed rats. Gut. 2011; 60: 238-46.
- Hwang R.F., Moore T., Arumugam T. et al. Cancer associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res. 2008; 68: 918-26.
- Erkan M., Kleeff J., Gorbachevski A. et al. Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity. Gastroenterology 2007; 132: 1447-64.
- Erkan M., Reiser-Erkan C., Michalski C.W. et al. Cancer stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma. Neoplasia 2009; 11: 497-508.
- Masamune A., Kikuta K., Watanabe T. et al. Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer. Am. J. Physiol. Gastrointest. Liver Physiol. 2008; 295: G709-17.
- Xu Z., Vonlaufen A., Phillips P.A. et al. Role of pancreatic stellate cells in pancreatic cancer metastasis. Am. J. Pathol. 2010; 177: 2585-96.
- Buchholz M., Kestler H.A., Holzmann K. et al. Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotype. J. Mol. Med. 2005; 83: 795-805.
- Erkan M., Weis N., Pan Z. et al. Organ-, inflammation and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells. Mol. Cancer. 2010; 9: 88.
- Mato E., Lucas M., Petriz J. et al. Identification of a pancreatic stellate cell population with properties of progenitor cells: new role for stellate cells in the pancreas. Biochem. J. 2009; 421: 181-91.
- Kordes C., Sawitza I., Gotze S. et al. Stellate Cells from Rat Pancreas Are Stem Cells and Can Contribute to Liver Regeneration. PLoS ONE 2012; 7: e51878. doi:10.1371/ journal. pone.
