Immunological properties of multipotent mesenchymal stromal cells
- 作者: Sergeev V.S.
- 期: 编号 2 (2005)
- 页面: 39-42
- 栏目: Mini-reviews
- ##submission.dateSubmitted##: 04.03.2023
- ##submission.dateAccepted##: 04.03.2023
- ##submission.datePublished##: 06.03.2023
- URL: https://genescells.ru/2313-1829/article/view/313380
- ID: 313380
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Figure 1. Five-day reaction of mixed culture of lymphocytes (MSCL).
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Figure 2. Possible mechanisms of immunological effects mediated by MMSC [MSC/SSC]:Activation of the recipient's lymphocyte T-cell receptor [TCR-CD3] without concomitant CD28 costimulation.Interaction of unknown surface molecules.MMSC secretion of prostaglandin E2 [PGE2].Induction of expression in MMSCs of the enzyme indoleamine 2,3-dioxygenase [IDO], which catalyzes the conversion of tryptophan to kynurein.MMSC secretion of transforming growth factor beta [TGF ß] and hepatocyte growth factor [HGF].MMSC secretion of an unknown soluble mediator with a pronounced immunosuppressive activity
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