Search of an optimum variant of cell therapy of a critical limbs ischemia in experiment
- Authors: Maslyanyuk, OV1, Alexandrov, VN1, Chirsky, VS1, Kriventsov, AV1, Maximov, AG1, Rumakin, VP1, Kalyuzhnaya LI1
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Affiliations:
- Federal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint Petersburg
- Issue: Vol 6, No 3 (2011)
- Pages: 41-45
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121549
- DOI: https://doi.org/10.23868/gc121549
- ID: 121549
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Abstract
maximal angiogenesis in ischemic limbs is urgent aim of
investigation for the right way of cell delivery other things
being equal is the main request for cell therapy efficiency.
On experimental model of critical ischemia (by angiographic
method and evaluation of capillary density on histological
sections) it was shown that cell therapy independently from
the way of cell injection (intramuscularly, intra-arterialy and
combined) induces angiogenesis, the rate and intensity of
which depend on the way of cell delivery. The optimum variant
of cell therapy of critical ischemia is combined (intramusculararterial)
method of cell injection, uniting the advantages of
intramuscular and intra-arterial ways.
About the authors
O V Maslyanyuk,
Federal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint PetersburgFederal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint Petersburg
V N Alexandrov,
Federal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint PetersburgFederal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint Petersburg
V S Chirsky,
Federal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint PetersburgFederal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint Petersburg
A V Kriventsov,
Federal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint PetersburgFederal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint Petersburg
A G Maximov,
Federal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint PetersburgFederal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint Petersburg
V P Rumakin,
Federal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint PetersburgFederal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint Petersburg
L I Kalyuzhnaya
Federal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint PetersburgFederal State Educational Institution of Higher Vocational Education «S. M.Kirov Military Medical academy»of the RF Ministry of Defense, Saint Petersburg
References
- Белевитин А.Б., Хубулава Г.Г., Сазонов А.Б. и др. Исполь- зование аутологичных стволовых клеток для стимуляции артерио- генеза при критической ишемии конечностей. Вестник Российской Военно-медицинской академии 2008; 3(23): 176-9.
- Масютин В.А., Широков Д.М., Пивоварова Л.П. и др. Оцен- ка лабораторных данных в критических состояниях. СПб: СПбГП, 1999.
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