Membrannyy potentsial igraet vazhnuyu rol' v differentsirovke MMSK
- Authors: Grigoryan AS1
-
Affiliations:
- Issue: Vol 4, No 1 (2009)
- Pages: 24-27
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121399
- DOI: https://doi.org/10.23868/gc121399
- ID: 121399
Cite item
Open Access
Access granted
Subscription or Fee Access
Abstract
Во время эмбрионального развития и регенерации тканей ключевую роль в процессах пролиферации и дифференцировки различных типов стволовых клеток и клеток-предшественниц играет не только молекулярная, но и биофизическая сигнализация, то есть биоэлектрические сигналы, генерируемые при участии ионных каналов, имеющихся в клеточной мембране И, 2]. Например, на модели дифференцировки клеток нейробла-стомы было продемонстрировано, что дифференцировка сопровождается деполяризацией мембраны, вызываемой работой калиевых и натриевых ионных каналов [3].
References
- Levin М. Large-scale biophysics: ion flows and regeneration. Trends in Cell Biology 2007; 17: 261-70.
- McCaig CD., Rajnicek A.M., Song В., Zhao M. Controlling cell behavior electrically: Current views and future potential. Physiological Reviews 2005; 85: 943-78.
- Arcangeli A., Rosati В., Crociani 0. et al. Modulation of HERG current and herg gene expression during retinoic acid treatment of human neuroblastoma cells: Potentiating effects of BDNF. Journal of Neurobiology 1ЭЭЭ; 40: 214-25.
- Zhao M., Song В., Pu J. et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-c and PTEN. Nature 2006; 442: 457-60.
- Song В., Zhao M., Forrester J.V., McCaig CD. Electrical cues regulate the orientation and frequency of cell division and the rate of wound healing in vivo. PNAS 2002; 99: 13577-82.
- Biagiotti Т., D'Amico M., Marzi I. et al. Cell renewing in neuroblastoma: Electrophysiological and immunocytochemical characterization of stem cells and derivatives. Stem Cells 2006; 24: 443-453.
- Cai J., Cheng A., Luo Y. et al. Membrane properties of rat embryonic multipotent neural stem cells. Journal of Neurochemistry 2004; 88: 212-26.
- Gersdorff Korsgaard M.P., Christophersen P., Ahring P.K., Olesen S.P. Identification of a novel voltage-gated Na+ channel rNav1.5a in the rat hippocampal progenitor stem cell line HiB5. Pflugers Archiv European Journal of Physiology 2001; 443: 18-30.
- Heubach J.F., Graf E.M., Leutheuser J. et al. Electrophysiological properties of human mesenchymal stem cells. Journal of Physiology 2004; 554: 659-72.
- Van Kempen M.J.A., Van Ginneken A., De Grijs I. et al. Expression of the electrophysiological system during murine embryonic stem cell cardiac differentiation. Cellular Physiology and Biochemistry 20D3; 13: 2B3-70.
- Cho Т., Bae J.H., Choi H.B. et al. Human neural stem cells: Electrophysiological properties of voltage-gated ion channels. NeuroReport 2002; 13: 1447-52.
- Konig S., Hinard V., Arnaudeau S. et al. Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation. Journal of Biological Chemistry 2004; 279: 28187-96.
- Sun W., Buzanska L, Domanska-Janik K. et al. Voltage-sensitive and ligand-gated channels in differentiating neural stem-like cells derived from the nonhematopoietic fraction of human umbilical cord blood. Stem Cells 2005; 23: 931-45.
- Fischer-Lougheed J., Liu J.H., Espinos E. et al. Human myoblast fusion requires expression of functional inward rectifier Kir2.1 channels. Journal of Cell Biology 2001; 153: 677-85.
- Liu J.H., Bijlenga P., Fischer-Lougheed J. et al. Role of an inward rectifier K+ current and of hyperpolarization in human myoblast fusion. Journal of Physiology 1998; 510: 467-76.
- Altizer A.M., Moriarty L.J., Bell S.M. et al. Endogenous electric current is associated with normal development of the vertebrate limb. Developmental Dynamics 2001; 221: 391-401.
- Avram M.M., Avram A.S., James W.D. Subcutaneous fat in normal and diseased states. 3. Adipogenesis: From stem cell to fat cell. Journal of the American Academy of Dermatology 2007; 56: 472-92.
- Spiegelman B.M. PPAR-c: Adipogenic regulator and thiazolidinedione receptor. Diabetes 1998; 47: 507-14.
- Zur Nieden N.I., Kempka G., Ahr H.J. In vitro differentiation of embryonic stem cells into mineralized osteoblasts. Differentiation 2003; 71: 18-27.
- Hoenicke E.M., Damiano Jr R.J. Superior 12-hour heart preservation with pinacidil hyperpolarizing solution compared to University of Wisconsin solution. Journal of Heart and Lung Transplantation 2001; 20: 1106-14.
- Lawson K. Potassium channel openers as potential therapeutic weapons in ion channel disease. Kidney International 2000; 57: 838-45.
- Nielsen-Kudsk J.E. Potassium channel modulation: A new drug principle for regulation of smooth muscle contractility. Studies on isolated airways and arteries. Danish Medical Bulletin 1996; 43: 429-47.
- Xiong Y., Harmon C.S. Evidence that diazoxide promotes calcium influx in mouse keratinocyte cultures by membrane hyperpolarization. Skin Pharmacology 1995; 8: 309-18.
Supplementary files
