Mesenchymal Stem Cells and Immunopathologie Conditions of a Human Body

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Abstract

Mesenchymal stem cells (MSC), multipotent stem cells of a grown human body are used more and more in clinical investigations. Their differentiation potential enables their application in traumatology, cardiology, neurology. However, more and more investigators consider therapeutic effectiveness of MSC transplantation proved by many preclinical and clinical studies to be due to not only differentiation but also a regulatory function of these cells. Application of MSC in immunopathologic conditions provides the opportunity to clarify their regulatory characteristics, ability to influence immune process within the body. Nowadays, there is a lot of experience of MSC usage in both different experimental models and in clinic. The present data analysis allows to discuss the influence of mesenchymal stem cells on separate parts of an immune system of the vertebrate.

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P. V. Kruglyakov

Trans-Technologies Lmd

Author for correspondence.
Email: redaktor@celltranspl.ru
Russian Federation, Saint-Petersburg

E. A. Lokhmatova

Saint-Petersburg State Pavlov University

Email: redaktor@celltranspl.ru
Russian Federation, Saint-Petersburg

V. B. Klimovich

Central Research Radiology Institute under the Federal Agency of Public Health and Social Development

Email: redaktor@celltranspl.ru
Russian Federation, Saint-Petersburg

A. Yu. Zaritsky

Saint-Petersburg State Pavlov University

Email: redaktor@celltranspl.ru
Russian Federation, Saint-Petersburg

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Supplementary files

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2. Fig. 1. The effect of allogeneic MSCs on the cells of the recipient's immune system

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3. Fig. 2. The effect of MSCs on the T-cell population

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