Transplantation of allogeneic mesenchymal stromal cell for treating corneal ulcers in cats

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Abstract

At present, a great interest for the veterinary practice is the use of stem cells to treat diseases of the eye. This study was conducted to evaluate the therapeutic effect of allogeneic multipotent mesenchymal stromal cells derived from adipose tissue for the treatment of traumatic corneal ulcers in cats Our results indicate that the stem cells stimulate regenerative processes in the damaged cornea

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About the authors

E. Y Zakirova

Kazan (Volga Region) Federal University Kazan, Russia

A. N Valeeva

Kazan State Academy of Veterinary Medicine Kazan, Russia

R. R Faizullina

Kazan State Academy of Veterinary Medicine Kazan, Russia

R. F Akhmetshin

Kazan State Medical University Kazan, Russia

L. V Nefedovskaya

Kazan (Volga Region) Federal University Kazan, Russia

A. A Rizvanov

Email: rizvanov@gmail.com
Kazan (Volga Region) Federal University Kazan, Russia

References

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  2. Hofstetter С., Schwarz E., Hess D. et al. Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc. Nat. Acad. Sci. USA. 2002; 99(4): 2199-204.
  3. Rama P., Matuska S., Paganoni G. et al. Limbal stem-cell therapy and long-term corneal regeneration. N. Engl. J. Med. 2010; 363: 147-55.
  4. Sel S., Schilling U.M., Nass N. et al. Bonemarrow cells and CD 117-positive haematopoietic stem cells promote corneal wound healing. Acta Ophthalmol. 2012; 90(5): 367-73.
  5. Ye J., Yao K., Kim J. С. Mesenchymal stem cell transplantation in a rabbit corneal alkali burn model: engraftment and involvement inw ound healing. Eye (Lond). 2006; 20(4): 482-90.

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