MicroRNAs in the regulation of osteogenesis in vitro and in vivo: from fundamental mechanisms to bone diseases pathogenesis



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Abstract

The review examined the participation of microRNA in the posttranscriptional regulation of the genes of the two main signaling pathways of osteogenic differentiation - canonical BMP/ SMAD and WNT/p-catenin. The positive and negative effects of microRNA on osteogenic differentiation in various cell cultures of humans and animals, including the choice of directions between adipo-, chondro- and osteogenesis, are indicated. The role of miRNA in the pathogenesis of bone tissue diseases and the prospects for developing methods for their diagnosis and therapy are described.

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About the authors

E. V Galitsyna

Research Centre for Medical Genetics

T. B Bukharova

Research Centre for Medical Genetics

A. V Vasilyev

Research Centre for Medical Genetics; Central Research Institute of Dental and Maxillofacial Surgery, Ministry of Health of the Russian Federation

D. V Goldshtein

Research Centre for Medical Genetics; M.V. Lomonosov Moscow State University

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