Gene therapy in regenerative medicine: latest achievements and actual directions of development



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Abstract

Gene therapy is a group of methods for treatment of various groups of diseases by replacement of damaged, introducing new genes or changing their expression. This is a new and actively developing area in biomedicine. Approaches to regulation of gene therapy drugs at all stages - from production, preclinical and clinical trials, as well as registration and marketing approval are not fully developed and regularly updated. This article provides an overview of worldwide approaches to conducting studies of gene therapy drugs and the procedures for their "accelerated registration”. This article as well summarizes our experience of Lomonosov Moscow State University in development of new direction vectors - gene therapy for the delivery of several therapeutic proteins. In the near future, this approach can be used to increase the effectiveness of gene therapy for stimulating vascular and axon growth, and tissue regeneration.

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About the authors

E. A Slobodkina

M.V. Lomonosov Moscow State University

Email: kslobodkina@mail.ru

M. N Karagyaur

M.V. Lomonosov Moscow State University

V. Yu Balabanyan

M.V. Lomonosov Moscow State University

P. I Makarevich

M.V. Lomonosov Moscow State University

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