Prospects of the tissue engineering lung development with the methods of regenerative medicine (review)



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Abstract

Deficit of donor organs, the need for lifelong immunosuppressive therapy, even in the case of successful lung transplantation, high risk of death in the postoperative period are forced to look for the new ways to treat terminally ill patients, requiring organ transplants. In the last decade, much attention is given to methods of regenerative medicine to repair or replace the function of damaged tissues and organs. Creating functional lungs in the laboratory will hopefully solve the problem of donor organs shortage. The study of morphological properties of biological scaffolds, deeper understanding of stem cells and progenitor cells behavior led to the idea of using decellularization methods followed by recellularization with autologous cells for tissue engineered trachea, lungs, heart and kidney creation Recellularized solid organs can perform organ-specific function in vitro conditions, indicating the potential clinical use of these methods This review presents the current data about lung decellularization and recellularization methods to increase efficiency and improve the quality of the biological scaffold and discusses the main aspects of lung transplantation in animal models and perspectives of lung bioengineering

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About the authors

E. V Kuevda

Kuban State Medical University

E. A Gubareva

Kuban State Medical University

Email: g_lena82@list.ru

A. S Sotnichenko

Kuban State Medical University

I. V Gilevich

Kuban State Medical University

I. S Gumenyuk

Kuban State Medical University

P. Macchiarini

Kuban State Medical University; Karolinska Institutet

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