Possible pathways of regener ative strategy in correction of type I diabetes mellitus by methods of cell transplantation

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Abstract

This review describes up to date concepts of pancreatic b-cell and islets of Langerhans physiological and reparative regeneration during type I diabetes mellitus. Modern approaches to recovery of lacking b-cell population with transplantation of allogenic islet cells, in vitro differentiated adult pancreatic progenitors or embryonic stem cells are considered. Possible pathways of in vivo tissue regeneration induction or immune correction in type I diabetes mellitus with bone marrow and cord blood stem cell therapy are analyzed.

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About the authors

A. R. Zakiryanov

Research institute of transplantology and artificial organs

Author for correspondence.
Email: logart@mail.ru

The stem cell biotechnology laboratory

Russian Federation, Moscow

N. A. Onishchenko

Research institute of transplantology and artificial organs

Email: logart@mail.ru

The stem cell biotechnology laboratory

Russian Federation, Moscow

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