Effect of Pluronic Р85 on proliferation and osteogenic differentiation of human mesenchymal stem cells in vitro



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Abstract

We investigated affect of non-ionic block copolymer (Pluronic) P85 on in vitro proliferation and osteogenic differentiation of human mesenchymal stem cells (MSCs). We demonstrated that Pluronic P85 at final concentration 0,1-1% was cytotoxic to MSCs. Addition of Pluronic P85 at final concentration 0,001-0,01% increased proliferation of MSCs. Pre-incubation of MSCs with Pluronic P85 increased osteogenic differentiation efficiency of cells.

About the authors

NL Blatt

M E Yalvach

A K Shafigullina

I I Salafutdinov

A L Kiyasov

R F Masgutov

YuG Shtyrlin

A V Kabanov

A A Rizvanov

N L Blatt

Kazan Federal University, Kazan

Kazan Federal University, Kazan

ME Yalvac

Yeditepe University, Istanbul, Turkey

Yeditepe University, Istanbul, Turkey

A K Shafigullina

Kazan State Medical University, Kazan

Kazan State Medical University, Kazan

I I Salafutdinov

Kazan Federal University, Kazan

Kazan Federal University, Kazan

A P Kiyasov

Kazan State Medical University, Kazan

Kazan State Medical University, Kazan

R E Masgutov

Kazan Federal University, KazanKazan State Medical University, Kazan

Kazan Federal University, KazanKazan State Medical University, Kazan

Y G Shtirlin

Kazan Federal University, Kazan

Kazan Federal University, Kazan

A V Kabanov

Medical Center of University of Nebraska, Omaha, USALomonosov Moscow State University, Moscow

Medical Center of University of Nebraska, Omaha, USALomonosov Moscow State University, Moscow

A A Rizvanov

Kazan Federal University, KazanYeditepe University, Istanbul, TurkeyKazan State Medical University, Kazan

Kazan Federal University, KazanYeditepe University, Istanbul, TurkeyKazan State Medical University, Kazan

References

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