Participation of the mononuclear cells of the cord blood in the physiologic regeneration of the rat kidney
- Authors: Yilmaz TS1, Mavlikeeva AV1, Gumerova AA1,2,3, Andreeva DI1, Fairushina IF1, Kiiasov AA1,2,3
-
Affiliations:
- Kazan State Medical University, Kazan
- Kazan Federal Volga Region University, Kazan
- Issue: Vol 7, No 3 (2012)
- Pages: 69-71
- Section: Articles
- URL: https://genescells.ru/2313-1829/article/view/121586
- DOI: https://doi.org/10.23868/gc121586
- ID: 121586
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Abstract
treatment of various diseases, including kidney pathology,
is widely investigated. Umbilical cord blood as the source of
hematopoietic stem cells becomes more and more promising.
The purpose of our investigation was to study homing and
ways of human umbilical cord blood mononuclear cells
differentiation in an intact rat kidney. We transplanted human
umbilical cord blood mononuclear cells fraction, enrich with
hematopoietic stem cells, into the tail vein of rats. On 2, 5,
7 and 14 days after transplantation paraffin kidney slices
were immunohistochemically stained with antibodies against
human leukocyte antigen (HLA-ABC) to study migration and
differentiation of transplanted cells. Results: HLA-ABC+-
cells were revealed in the epithelium of the distal tubule at all
experimental dates. But HLA-ABC was expressed not in each
distal tubule and not by all tubular cells. We concluded that
human umbilical cord blood mononuclear cells transplanted into
systemic circulation of rat migrate into the intact kidney and
built in the distal tubule epithelium. This data allow to suggest
that distal tubule are stem cell «niche» in the kidney.
About the authors
T S Yilmaz
Kazan State Medical University, KazanKazan State Medical University, Kazan
A V Mavlikeeva
Kazan State Medical University, KazanKazan State Medical University, Kazan
A A Gumerova
Kazan State Medical University, Kazan;Kazan Federal Volga Region University, Kazan;Kazan State Medical University, Kazan;Kazan Federal Volga Region University, Kazan;
D I Andreeva
Kazan State Medical University, KazanKazan State Medical University, Kazan
I F Fairushina
Kazan State Medical University, KazanKazan State Medical University, Kazan
A A Kiiasov
Kazan State Medical University, Kazan;Kazan Federal Volga Region University, Kazan;Kazan State Medical University, Kazan;Kazan Federal Volga Region University, Kazan;
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