Gene and cell therapy of retinal diseases

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Abstract

Gene and cell therapy are tightly associated and quickly
developing areas of biomedicine, which purpose is development
of methods to cure diseases caused by genetic defects and/or
death of certain cell types. Current state of methods of retinal
diseases gene and cell therapy is analyzed in this review. We
reviewed development of gene therapeutic approaches to
treatment of the 2-nd form of Lebers congenital amaurosis
and other retinal diseases. We also compared therapeutic
potential of pluripotent stem cells and human adult retinal
stem cells. Therapeutic potential of pluripotent stem cells
seems to be better due to their ability for unlimited expansion
and organogenesis.

About the authors

V V Maximov

Vavilov Institute of General Genetics of RAS, Moscow

Vavilov Institute of General Genetics of RAS, Moscow

M A Lagarkova

Vavilov Institute of General Genetics of RAS, Moscow

Vavilov Institute of General Genetics of RAS, Moscow

S L Kiselev

National Research Centre «Kurchatov Institute», Moscow

National Research Centre «Kurchatov Institute», Moscow

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