Umbilical cord blood as a source for allogeneic stem cell transplantation in children (the experience of Moscow Stem Cell Bank)



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Abstract

The results of hematopoetic stem cell transplantation [HSCTJ of cord blood units collected by Stem Cell Bank of Moscow are described. From August 200Б till August 2009 1Б children with malignant hematological and non-malignant diseases have undergone umbilical cord blood transplantation ШСВТ). The median number of total nucleated cells and CD34+ cells infused was B,Ox107/kg [range 0,2-21,5) and 7,7x105/kg [range 0,5-40), accordingly. 9 (5B,25%) patients showed engraftment. The median time to neutrophil engraftment was 24 days [range 15-ЗБ). Acute GVHD grade l-ll was observed in 7[43,75%) patients, there were no cases of severe GVHD. Chronic GVHD was noted in KB,25%) patient. The transplant-related mortality at 100 days was 28,5%. The overall survival was 5B,2%, with a median time of observation of 11Б days. The results of our study showed that UCB is an alternative source of stem cells for HSCT in patients with malignant and non-malignant diseases.

About the authors

T V Shamanskaya

T A Astrelina

Z A Podkolzina

E E Karpova

L L Lebedeva

E E Skorobogatova

O B Paina

M B Yakovleva

T V Shamanskaya

Stem Cell Bank, MoscowFederal Clinical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow

Stem Cell Bank, MoscowFederal Clinical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow

Т А Astrelina

Stem Cell Bank, MoscowFederal Clinical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow

Stem Cell Bank, MoscowFederal Clinical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow

E A Podkolzina

Stem Cell Bank, Moscow

Stem Cell Bank, Moscow

E E Karpova

Stem Cell Bank, Moscow

Stem Cell Bank, Moscow

L L Lebedeva

Stem Cell Bank, Moscow

Stem Cell Bank, Moscow

E V Skorobogatova

Federal Clinical Research Center of Pediatric Hematology, Oncology and Immunology, MoscowRussian Children Clinical Hospital, Moscow

Federal Clinical Research Center of Pediatric Hematology, Oncology and Immunology, MoscowRussian Children Clinical Hospital, Moscow

O V Paina

St. Peterburg Pavlov State Medical University, Memorial R.M. Gorbacheva Institute of Children Hematology, St. Peterburg

St. Peterburg Pavlov State Medical University, Memorial R.M. Gorbacheva Institute of Children Hematology, St. Peterburg

M V Yakovleva

Stem Cell Bank, Moscow

Stem Cell Bank, Moscow

References

  1. Gluckman Е. Cord Blood Transplantation. Biol. Blood Marrow Transplant. 2006; 12(8): 808-12.
  2. Rocha V., Gluckman E., Eurocord and European Blood and Marrow Transplant Group. Clinical use of umbilical cord blood hematopoietic stem cells. Biol. Blood Marrow Transplant. 2006; 12 (1 Suppl 1): 34-41.
  3. The World Marrow Donor Association. <http://> www.worldmarrow.org/ <http://www.worldmarrow.org/>.
  4. Majhail N.S., Brunstein C.G., Wagner J.E. Double umbilical cord blood transplantation. Curr. Opin. Immunol. 2006; 18(5): 571-5.
  5. Gluckman E., Broxmeyer H.A., Auerbach A.D. et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N. Engl. J. Med. 1989; 321(17): 1174-8.
  6. Rubinstein P., Taylor P.E., Scaradavou A. et al. Unrelated placental cord blood for bone marrow reconstitution organization of the placental blood program. Blood Cells 1994; 20(2-3): 587-96.
  7. NETCORD. <http://www.netcord.org>.
  8. Navarrete C, Contreras M. Cord blood banking: a historica perspective. Br. J. Haematol. 2009; 147(2): 236-45.
  9. Novelo-Garza В., Limon-Flores A., Guerra-Marquez A. et al. Establishing a cord blood banking and transplantation program in Mexico: a single institution experience. Transfusion 2008; 48(2): 228-36.
  10. Wu J.Y., Liao C, XuZ.P. et al. Banking and transplantation of umbilical cord blood in Guangzhou, China. Cytotherapy 2006; 8(5): 488-97.
  11. Van Rood J.J., Oudshoorn M. Eleven million donors in Bone Marrow Donors Worldwide! Time for reassessment? Bone Marrow Transplant 2008; 41(1): 1-9.
  12. QuerolS., Rubinstein P., Marsh S.G. E. etal. Cord blood banking: «providing cord blood banking for a nation». Br. J. Haematol. 2009; 147(2): 227-35.
  13. Barker J.N., Weisdorf D.J., Defor Т.Е. et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005; 105: 1343-7.

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