Modern approaches to peripheral nerve regeneration after injury: the prospects of gene and cell therapy



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Abstract

Natural potency of peripheral nerves to regenerate after injury is limited by time and ability of neurons to recuperate. It results in loss of function and disability of impaired subject. Existing therapeutic approaches are not capable to support nerve survival and neurite outgrowth for a sufficient period of time. This problem can be solved by application of novel gene therapeutic drugs and cell-based approaches. Present review focuses on mechanisms of nerve repair and key stages of peripheral nerve system regeneration after injury. The study provides a systematic overview of biologically active molecules involved and gives a prospect of new methods in treatment of injured nerves.

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About the authors

M. N Karagyaur

Lomonosov Moscow State University; Institute of Experimental Cardiology, Russian Cardiology Research and Production Complex

Moscow, Russia

P. I Makarevich

Lomonosov Moscow State University; Institute of Experimental Cardiology, Russian Cardiology Research and Production Complex

Moscow, Russia

E. K Shevchenko

Lomonosov Moscow State University; Institute of Experimental Cardiology, Russian Cardiology Research and Production Complex

Moscow, Russia

D. V Stambolsky

Lomonosov Moscow State University; Institute of Experimental Cardiology, Russian Cardiology Research and Production Complex

Moscow, Russia

N. I Kalinina

Lomonosov Moscow State University

Moscow, Russia

Ye. V Parfyonova

Lomonosov Moscow State University; Institute of Experimental Cardiology, Russian Cardiology Research and Production Complex

Moscow, Russia

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