Application of tissue engineered constructs on the basis of cell sheets FOR RESTORATION OF TISSUES AND ORGANS



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Abstract

Cell sheet technology has certain advantages over conventionally used injections as far as it facilitates cell survival and integration after delivery of cells to intended organ/tissue. It also allows to successfully replace lost or irreversibly damaged tissues with restoration of its functions including endo/paracrine activity. Application of cell sheets has gone beyond bench work and now is under clinical translation where it is successfully used for repair of cornea, cartilage, periodontal tissue, esophageal mucosa, pancreas and thyroid gland. Further advances of cell sheet technologies allow to construct pre-vascularized tissue grafts which effects are not limited to tissue repair, but also allows to restore its function via paracrine action of transplanted cells and to ensure long-lasting therapeutic effects. Genetic modification of cells used for cell sheet construction allows to utilize this technology to treat hereditary disorders, deficit of enzymes or other secreted proteins. This review focuses on recent results of therapeutic implication of cell sheets and prospects of this field which gained much attention in regenerative medicine.

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About the authors

K. V Dergilev

Institute of Experimental Cardiology, Russian Cardiology Research and Production Complex

Moscow, Russia

P. I Makarevich

Institute of Experimental Cardiology, Russian Cardiology Research and Production Complex

Moscow, Russia

M. Yu Menshikov

Institute of Experimental Cardiology, Russian Cardiology Research and Production Complex

Moscow, Russia

E. V Parfyonova

Institute of Experimental Cardiology, Russian Cardiology Research and Production Complex

Moscow, Russia

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