Prospects for tissue engineered bile duct

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Abstract

Intraoperative bile duct injures requiring its repair observed in 0. 05-2. 7% of patients, who underwent cholecystectomy due to cholelithiasis Lots of patients require reconstructive bile duct surgery given that cholecystectomy is the second most common surgery in the abdominal region, and more than 1 mln operations are made all over the world per year. Previously stitching of the crossed bile duct edges was used, but in most cases this entailed the bile duct stricture and disturbance of the bile outflow. At present, the standard surgery includes suturing of the duct with small intestine, but such a reconstruction, in turn, can lead to liver abscess, biliary cirrhosis and increased risk of cholangiocarcinoma. in this review, we consider the possibility of creating fragments of tissue-engineered bile duct that involves the use multilayer tissue-engineered structures consisting of a composite matrix, cells and signaling molecules that stimulate local proliferation and neovascularization.

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About the authors

T. G Dyuzheva

Sechenov First Moscow State Medical University

A. V Lyundup

Sechenov First Moscow State Medical University

I. D Klabukov

Sechenov First Moscow State Medical University

Email: ilya.klabukov@gmail.com

S. N Chvalun

National Research Center “Kurchatov Institute"

T. E Grigorev

National Research Center “Kurchatov Institute"

A. D Shepelev

National Research Center “Kurchatov Institute"

T. H Tenchurin

National Research Center “Kurchatov Institute"

M. E Krasheninnikov

Sechenov First Moscow State Medical University

R. V Oganesyan

Sechenov First Moscow State Medical University

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