Umbilical cord-derived multipotent mesenchymal stromal cells: biological properties and clinical applications



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Abstract

The article presents the current literature evidence and own data on the origin and properties of human umbilical cord-derived multipotent mesenchymal stromal cells including proliferative potential, plasticity, stability of caryotype and phenotype, and immunomodulatory activity A review of clinical trials using this cell type is performed Prospects for the use of multipotent stromal cells, derived from umbilical cord, in cell transplantation associate with the need for specialized biobanking and transplant standardization criteria

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About the authors

I. V Arutyunyan

V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology of Ministry of Healthcare of the Russian Federation; Scientific Research Institute of Human Morphology

A. V Makarov

V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology of Ministry of Healthcare of the Russian Federation; Scientific Research Institute of Human Morphology; N.I. Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation

A. V Elchaninov

V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology of Ministry of Healthcare of the Russian Federation; Scientific Research Institute of Human Morphology; N.I. Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation

T. Kh Fatkhudinov

V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology of Ministry of Healthcare of the Russian Federation; Scientific Research Institute of Human Morphology; N.I. Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation

Email: fatkhudinov@gmail.com

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