Regeneration therapy of chronic hepatitis and hepatic cirrhosis by fetal tissue transplantation

То evaluate feasibility of fetal tissue transplantation as a new noninvasive technique to stimulate liver regeneration in case of chronic hepatitis and hepatic cirrhosis.

According to biochemical studies patients with CH who underwent FTT demonstrated significant decrease (p<0,05) of AST, ALT, α2 and γ-giobuiins, thymol challenge, alkaline phosphatase when opposed to the comparison group, in these cases stable remission was observed in 73% while in the comparison group only 33%. In patients with HC fetal tissue transplantation induced disease improvement in 70% compared to 36% of cases undergoing conventional therapy in the comparison group. We observed significant difference [p<0,05] in the level of albumin, α2 and γ-globulins, AcAT, alkaline phosphatase, γ-GTP, thymol challenge comparing the findings according to biochemical studies. Patients with PBC having the several consequent therapy showed decreased severity of cholestasis syndrome and slower progression of the disease according to the clinical and biochemical studies when compared to the control group.

According to our data FTT is indicated to patients with CH and HC in mild and moderate stages. If the condition is severe and there is virus replication observed it is necessary to start etiotropic and immunosuppressive therapy and then it might be possible to perform FTT.