Postinfarction cellular regeneration therapy of the heart muscle

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Abstract

Cellular regeneration therapy is a promising new way to treat diseases of the cardiovascular system. This review examines various experimental and clinical approaches to cell regeneration therapy, such as: local cytokine therapy, stimulation of the release of resident bone marrow stem cells and stem cell transplantation itself. The paper presents a detailed analysis of various types of donor cells used for cellular cardiomyoplasty in experimental and clinical studies. Particular attention is paid to the discussion of methods of cell delivery to the area of the damaged myocardium and methods of graft imaging.

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A. V. Kurtova

Laboratory of Clinical Immunology and Molecular Diagnostics, St. Petersburg State Medical University Academician I.P. Pavlov; St. Petersburg State University

Author for correspondence.
Email: redaktor@celltranspl.ru

Department of Cytology and Histology, Faculty of Biology and Soil

Russian Federation, Saint Petersburg; Saint Petersburg

E. E. Zueva

Laboratory of Clinical Immunology and Molecular Diagnostics, St. Petersburg State Medical University Academician I.P. Pavlov

Email: redaktor@celltranspl.ru
Russian Federation, Saint Petersburg

A. S. Nemkov

St. Petersburg State Medical University named after Academician I.P. Pavlov

Email: redaktor@celltranspl.ru

Department of Faculty Surgery

Russian Federation, Saint Petersburg

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2. Fig. 1. Cells transplanted in myocardial infarction and their therapeutic potential

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3. Fig. 2. Methods of delivery of stem cells to the myocardium

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