Prospects for the use of pluripotent stem cells derived blood components: erythropoiesis

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Abstract

We review the problem of producing erythroid cells from human pluripotent stem cells. Pluripotent stem cells (embryonic stem cells, and induced pluripotent stem cells) are capable of self-renewal and differentiation into all cell types of an organism, including blood cells. Since a worldwide problem of blood donation shortage is very serious, the development of technologies to produce blood from pluripotent cells is a very modern and necessary task, which is the subject of investigations of many laboratories around the world.

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E. S Philonenko

Vavilov Institute of General Genetics of RAS, Moscow

M. A Lagarkova

Vavilov Institute of General Genetics of RAS, Moscow

S. L Kiselev

Vavilov Institute of General Genetics of RAS, Moscow

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