Prospects of increasing the effectiveness of cardio-vascular gene and cell therapy: genetically modified cells



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Abstract

Many hopes for increasing the effectiveness of therapy for cardio-vascular diseases such as non optimal for cases of ischemic heart diseases, myocardial infarction, heart failure, critical limb ischemia are connected with progress in gene and cell therapy. Experimental studies strongly demonstrated effective angiogenesis and myocardial regeneration, blood flow restoration in ischemic limb by gene and cell therapy approaches. However the results of clinical studies of these methods are very modest. To overcome the insufficient effectiveness of these methods the genetic modification of stem and progenitor cells - an alliance of gene and cell therapy allowing to neutralize disadvantages and to enhance advantages of both methods - could be used. In this review we have provided an overview of pioneering research in the experimental application of genetically engineered cells in cardiovascular pathology. The possibility of using genetically modified progenitor cells of different origin for therapeutic angiogenesis, myocardial regeneration and creation of cardiac pacemakers is discussed.

About the authors

E K Shevchenko

A K Talitskiy

E V Parfenova

E K Shevchenko

Russian Cardiology Research and Production Complex, Moscow

Russian Cardiology Research and Production Complex, Moscow

A K Talitskiy

Russian Cardiology Research and Production Complex, Moscow

Russian Cardiology Research and Production Complex, Moscow

Y V Parfyonova

Russian Cardiology Research and Production Complex, Moscow

Russian Cardiology Research and Production Complex, Moscow

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