Conduit based on poly(ε-caprolactone) filled with fibrin-based hydrogel with mesenchymal stromal cells for peripheral nerve defect reconstitution



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Abstract

In this study we used promising therapeutic strategy for stimulation of peripheral nerve regeneration - implantation of poly(ε-caprolactone) nerve conduit filled with fibrin hydrogel Tissucol in combination with mesenchymal stem cells. In vitro studies showed that the coating by Tissucol of poly(ε-caprolactone) substrate promotes cell proliferation. In vivo results of peripheral nerve defect reconstitution in rats using the conduit based on poly (ε-caprolactone) filled with fibrin hydrogel with mesenchymal stem cells confirmed the effectiveness of the proposed approach

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About the authors

Y. O Mukhamedshina

Kazan (Volga region) Federal University Kazan, Russia

R. F Masgutov

Kazan (Volga region) Federal University Republic Clinical Hospital Kazan, Russia

G. A Masgutova

Kazan (Volga region) Federal University Kazan, Russia

M. N Zuravleva

Kazan (Volga region) Federal University Kazan, Russia

A. P Shulman

Republic Clinical Hospital Kazan, Russia

L. R Galieva

Kazan (Volga region) Federal University Kazan, Russia

A. F Rogozin

Kazan (Volga region) Federal University Republic Clinical Hospital Kazan, Russia

Y. A Chelyshev

Kazan (Volga region) Federal University Kazan State Medical University Kazan, Russia

A. A Rizvanov

Kazan (Volga region) Federal University Kazan, Russia

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