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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Genes &amp; Cells</journal-id><journal-title-group><journal-title xml:lang="en">Genes &amp; Cells</journal-title><trans-title-group xml:lang="ru"><trans-title>Гены и Клетки</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Genes and Cells</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-1829</issn><issn publication-format="electronic">2500-2562</issn><publisher><publisher-name xml:lang="en">Human Stem Cells Institute</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">545830</article-id><article-id pub-id-type="doi">10.23868/gc545830</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original Study Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Transspinal direct current stimulation with an intensity of 2.5 mA does not affect the corticospinal system excitability and motor skills</article-title><trans-title-group xml:lang="ru"><trans-title>Транс-спинальная стимуляция с интенсивностью 2,5 мА не влияет на активность кортикоспинальной системы и моторные навыки</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0420-0221</contrib-id><name-alternatives><name xml:lang="en"><surname>Pomelova</surname><given-names>Ekaterina D.</given-names></name><name xml:lang="ru"><surname>Помелова</surname><given-names>Екатерина Дмитриевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>epomelova@hse.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4413-9421</contrib-id><name-alternatives><name xml:lang="en"><surname>Popyvanova</surname><given-names>Alyona V.</given-names></name><name xml:lang="ru"><surname>Попыванова</surname><given-names>Алена Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>apopyvanova@hse.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8291-6180</contrib-id><contrib-id contrib-id-type="spin">1977-3198</contrib-id><name-alternatives><name xml:lang="en"><surname>Bredikhin</surname><given-names>Dmitry O.</given-names></name><name xml:lang="ru"><surname>Бредихин</surname><given-names>Дмитрий Олегович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Student</p></bio><bio xml:lang="ru"><p>аспирант</p></bio><email>dbredihin@hse.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6737-550X</contrib-id><name-alternatives><name xml:lang="en"><surname>Koriakina</surname><given-names>Maria M.</given-names></name><name xml:lang="ru"><surname>Корякина</surname><given-names>Мария Михайловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Student</p></bio><bio xml:lang="ru"><p>аспирант</p></bio><email>maria_kore@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9374-9878</contrib-id><contrib-id contrib-id-type="spin">6010-6538</contrib-id><name-alternatives><name xml:lang="en"><surname>Shestakova</surname><given-names>Anna N.</given-names></name><name xml:lang="ru"><surname>Шестакова</surname><given-names>Анна Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Biol.)</p></bio><bio xml:lang="ru"><p>к.б.н.</p></bio><email>a.shestakova@hse.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0955-6633</contrib-id><contrib-id contrib-id-type="spin">2811-5723</contrib-id><name-alternatives><name xml:lang="en"><surname>Blagovechtchenski</surname><given-names>Evgeny D.</given-names></name><name xml:lang="ru"><surname>Благовещенский</surname><given-names>Евгений Дмитриевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Biol.)</p></bio><bio xml:lang="ru"><p>к.б.н.</p></bio><email>eblagovechensky@hse.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">National Research University Higher School of Economics</institution></aff><aff><institution xml:lang="ru">Национальный исследовательский университет «Высшая школа экономики»</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2023-10-13" publication-format="electronic"><day>13</day><month>10</month><year>2023</year></pub-date><pub-date date-type="pub" iso-8601-date="2023-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2023</year></pub-date><volume>18</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>381</fpage><lpage>388</lpage><history><date date-type="received" iso-8601-date="2023-07-11"><day>11</day><month>07</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-08-18"><day>18</day><month>08</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Эко-Вектор</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2027-02-20"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://genescells.ru/2313-1829/article/view/545830">https://genescells.ru/2313-1829/article/view/545830</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND</bold><italic>:</italic> Noninvasive brain stimulation effectively affects movements, including the spinal cord level. Stimulation effects are very sensitive to montage and protocols of applied stimulation because they can involve different neuronal mechanisms.</p> <p><bold>AIM</bold><italic>:</italic> This study aimed to estimate the effect of anodal transspinal direct current stimulation (tsDCS) with an intensity of 2.5 mA applied at the spinal cord level (C7–Th1 segments) with cervical enlargement on the corticospinal system excitability and motor skills.</p> <p><bold>METHODS</bold><italic>: </italic>The study involved 54 healthy adults aged 21.19±3.20 years. The effect of tsDCS was assessed using motorevoked potentials from the first dorsal interosseous (FDI) muscle by transcranial magnetic stimulation in the primary motor cortex before stimulation, immediately after stimulation, and after 15 min.</p> <p><bold>RESULTS</bold><italic>:</italic> The application of an 11-min anodal tsDCS with a current value of 2.5 mA at the C7–Th1 level did not affect the motorevoked potentials of FDI. Statistically, changes in motorevoked potentials amplitudes did not differ between groups receiving anodal tsDCS and sham stimulation. In addition, anodal tsDCS did not affect motor skills. An individual’s ability to coordinate fingers and manipulate objects effectively (a measure of dexterity) in the nine-hole peg test and pressing a key in response to a visual stimulus in the serial reaction time task did not differ from that with sham stimulation.</p> <p><bold>CONCLUSION</bold><italic>:</italic> 2.5 mA anodal tsDCS on cervical enlargement does not affect the corticospinal system excitability or change motor skills associated with precise hand movements.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование</bold>. Неинвазивная стимуляция мозга является эффективным способом воздействия на двигательные пути человека на уровне как головного, так и спинного мозга. Известно, что разные параметры и монтажи одной и той же стимуляционной процедуры могут существенно влиять на результаты, так как вовлекают разные нейрональные механизмы.</p> <p><bold>Цель</bold> — оценить влияние анодной транс-спинальной стимуляции постоянным током (tsDCS) интенсивностью 2,5 мА на уровне шейного утолщения спинного мозга (сегменты С7–Th1) на возбудимость кортикоспинальной системы и коррекцию двигательных навыков здорового человека.</p> <p><bold>Материал и методы</bold>. В исследовании приняли участие 54 здоровых взрослых человека в возрасте 21,19±3,20 года. Эффект tsDCS оценивали с помощью вызванных моторных ответов от первой дорсальной межкостной (FDI) мышцы путём транскраниальной магнитной стимуляции в первичной моторной коре в трёх временн΄ых периодах: до стимуляции, сразу после и через 15 мин после стимуляции.</p> <p><bold>Результаты</bold>. Применение 11-минутной анодной tsDCS на уровне шейного утолщения спинного мозга (C7–Th1) с интенсивностью 2,5 мА не оказывает влияния на изменение амплитуды вызванных моторных ответов мышцы FDI. Статистический анализ показал, что динамика амплитуды вызванных моторных ответов не отличалась между группами, получавшими анодную tsDCS и плацебо-стимуляцию. Анодная tsDCS не влияла также на двигательные навыки. Способность человека эффективно манипулировать мелкими объектами (показатель ловкости рук) в тесте с девятью отверстиями (9-HPT) и нажимать клавишу в ответ на визуальный стимул в задании на время последовательной реакции (SRT) не отличалась от плацебо-стимуляции.</p> <p><bold>Заключение</bold>. Можно предположить, что анодная tsDCS с интенсивностью 2,5 мА на уровне шейного утолщения спинного мозга (сегменты С7–Th1) не влияет на возбудимость кортикоспинальной системы и не изменяет двигательные навыки, связанные с точными движениями рук.</p></trans-abstract><kwd-group xml:lang="en"><kwd>transspinal direct current stimulation</kwd><kwd>transcranial magnetic stimulation</kwd><kwd>motor evoked potentials</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>транс-спинальная стимуляция постоянным током</kwd><kwd>транскраниальная магнитная стимуляция</kwd><kwd>вызванные моторные ответы</kwd></kwd-group><funding-group><funding-statement xml:lang="en">The studies were carried out using the Unique Scientific Installation of the National Research University Higher School of Economics, “Automated System for Non-Invasive Brain Stimulation with the Possibility of Synchronous Registration of Brain Biocurrents and Eye Movement Tracking”; with the financial support of the Ministry of Science and Higher Education of the Russian Federation, grant N 075-15-2021-673</funding-statement><funding-statement xml:lang="ru">Исследования были проведены с использованием уникальной научной установки НИУ ВШЭ «Автоматизированная система неинвазивной стимуляции мозга с возможностью синхронной регистрации биотоков мозга и отслеживания глазодвижения»; при финансовой поддержке Министерства науки и высшего образования Российской Федерации, грант № 075-15-2021-673</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Popyvanova AV, Koriakina MA, Pomelova ED, et al. 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