<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="brief-report" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Genes &amp; Cells</journal-id><journal-title-group><journal-title xml:lang="en">Genes &amp; Cells</journal-title><trans-title-group xml:lang="ru"><trans-title>Гены и Клетки</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Genes and Cells</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-1829</issn><issn publication-format="electronic">2500-2562</issn><publisher><publisher-name xml:lang="en">Human Stem Cells Institute</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">313354</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Cell technology</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Новости клеточных технологий</subject></subj-group><subj-group subj-group-type="article-type"><subject>Short Communication</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Genomic changes in human embryonic stem cells during long-term cultivation</article-title><trans-title-group xml:lang="ru"><trans-title>Геномные изменения эмбриональных стволовых клеток человека при длительном культивировании</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Melikhova</surname><given-names>V. S.</given-names></name><name xml:lang="ru"><surname>Мелихова</surname><given-names>B. C.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution></institution></aff><pub-date date-type="pub" iso-8601-date="2005-07-06" publication-format="electronic"><day>06</day><month>07</month><year>2005</year></pub-date><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>16</fpage><lpage>17</lpage><history><date date-type="received" iso-8601-date="2023-03-04"><day>04</day><month>03</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-03-04"><day>04</day><month>03</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Эко-Вектор</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://genescells.ru/2313-1829/article/view/313354">https://genescells.ru/2313-1829/article/view/313354</self-uri><abstract xml:lang="ru"><p/></abstract><trans-abstract xml:lang="en"><p/></trans-abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Brimble S.N., Zeng X., Weiler D.A. et al. Karyotypic stability, genotyping, differentiation, feeder-free maintenance, and gene expression sampling in three human embryonic stem cell lines derived prior to August 9, 2001. Stem Cells Dev. 2004; 13: 585-97.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Buzzard J.J., Gough N.M., Crook J.M., Colman A. Karyotype of human ES cells during extended culture. Nat. Biotechnol. 2004; 22: 381 -2.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Rosler E.S., Fisk G.J., Ares X. et al. Long-term culture of human embryonic stem cells in feeder-free conditions. Dev. Dyn. 2004; 229: 259-74.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Draper J.S., Smith K., Gokhale P. et al. Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat Biotechnol. 2004; 22: 53-4.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Matsuzaki H., Dong S., Loi H. et al. Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays. Nat Methods 2004; 1: 109-11.</mixed-citation></ref></ref-list></back></article>
