Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute27551710.23868/gc275517ReviewsНаучные обзорыReview ArticleMesenchymal Stem Cells and Immunopathologie Conditions of a Human BodyМезенхимные стволовые клетки и иммунопатологические состояния организмаKruglyakovP. V.КругляковП. В.
Russian Federation
redaktor@celltranspl.ruLokhmatovaE. A.ЛохматоваЕ. А.
Russian Federation
redaktor@celltranspl.ruKlimovichV. B.КлимовичВ. Б.
Russian Federation
redaktor@celltranspl.ruZaritskyA. Yu.ЗарицкийА. Ю.
Russian Federation
redaktor@celltranspl.ruTrans-Technologies LmdООО «Транс-Технологии»Saint-Petersburg State Pavlov UniversityСанкт-Петербургский Государственный университет им. И. П. ПавловаCentral Research Radiology Institute under the Federal Agency of Public Health and Social DevelopmentГУ «Центральный научно-исследовательский рентгенорадиологический институт Федерального агентства по здравоохранению и социальному развитию»150320061336412202202322022023Copyright ©; 2006, Eco-VectorCopyright ©; 2006, Эко-Вектор2006Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/275517

Mesenchymal stem cells (MSC), multipotent stem cells of a grown human body are used more and more in clinical investigations. Their differentiation potential enables their application in traumatology, cardiology, neurology. However, more and more investigators consider therapeutic effectiveness of MSC transplantation proved by many preclinical and clinical studies to be due to not only differentiation but also a regulatory function of these cells. Application of MSC in immunopathologic conditions provides the opportunity to clarify their regulatory characteristics, ability to influence immune process within the body. Nowadays, there is a lot of experience of MSC usage in both different experimental models and in clinic. The present data analysis allows to discuss the influence of mesenchymal stem cells on separate parts of an immune system of the vertebrate.

Мезенхимные стволовые клетки (МСК) - плюрипотентные стволовые клетки взрослого организма все чаще и чаще находят применение в клинических исследованиях. Их применение в травматологии, кардиологии, неврогии обусловлено их дифференцировочным потенциалом. Однако все большее количество исследователей считает что терапевтический эффект трансплантации МСК, доказанный во многих доклинических и клинических исследованиях, определяется не только дифференцировкой, но регуляторной функцией этих клеток. Применение МСК при иммунопатологических состояниях - возможность выяснить их регуляторные свойства, их способность влиять на иммунные процессы организма. На сегодняшний день накоплен опыт применения МСК как на различных экспериментальных моделях, так и в клинике. Анализ существующих данных позволяет нам рассуждать о влиянии МСК на отдельные компоненты иммунной системы позвоночных.

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