Genes & CellsGenes & Cells2313-18292500-2562Human Stem Cells Institute26133410.23868/gc261334Research ArticleTransplantation of multi-potent mesenchymal stromal cells for the treatment of graft-versus-host reactionGrigoryanA. S.redaktor@celltranspl.ru150320061331322102202321022023Copyright © 2006, Eco-Vector2006[Thomas E.D., Buckner C.D., Banaji M. et al. One hundred patients with acute leukaemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation. Blood 1977; 49: 511 -33.][Appelbaum F. The current status of hematopoietic cell transplantation. Annu. Rev. Med. 2003; 54: 491-512.][Aschan J. Treatment of moderate to severe acute graft-versus-host disease: a retrospective analysis. Bone Marrow Transplant. 1994; 14: 601 -7.][Angeloupoulou M., Novelli E., Grove J.E. et al. Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice. Exp. Hematol. 2003; 31: 413-20.][Maitra B., Szekely E., Gjini K. et al. Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation. Bone Marrow Transplant. 2004; 33: 597-604.][Tse W.T., Pendleton J.D., Beyer W.M. et al. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 2003; 75: 389-97.][Klyushnenkova E., Mosca J.D., Zernetkina V. et al. T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance and suppression. Biomed. Science 2005; 12: 47-57.][Rasmusson I., Ringde' n O., Sundberg B. et al. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation 2003; 76: 1208.][Le Blanc K., Rasmusson I., Sundberg B. et al. Treatment of severe acute graft-versus-host disease with third party haplo-identical mesenchymal stem cells. Lancet 2004; 363: 1439-41.]