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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Genes &amp; Cells</journal-id><journal-title-group><journal-title xml:lang="en">Genes &amp; Cells</journal-title><trans-title-group xml:lang="ru"><trans-title>Гены и Клетки</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Genes and Cells</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-1829</issn><issn publication-format="electronic">2500-2562</issn><publisher><publisher-name xml:lang="en">Human Stem Cells Institute</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">133727</article-id><article-id pub-id-type="doi">10.23868/202209010</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Discussion and general theoretical works</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Дискуссионные и общетеоретические работы</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Morphogenesis of the gall bladder — a mystery of the XXI century</article-title><trans-title-group xml:lang="ru"><trans-title>Морфогенез желчного пузыря — загадка XXI века</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Oripov</surname><given-names>F. S.</given-names></name><name xml:lang="ru"><surname>Орипов</surname><given-names>Ф. С.</given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><email>redactor@genescells.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dekhkanov</surname><given-names>T. D.</given-names></name><name xml:lang="ru"><surname>Дехканов</surname><given-names>Т. Д.</given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><email>redactor@genescells.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Samarkand State Medical University</institution></aff><aff><institution xml:lang="ru">Самаркандский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-09-25" publication-format="electronic"><day>25</day><month>09</month><year>2022</year></pub-date><volume>17</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>67</fpage><lpage>69</lpage><history><date date-type="received" iso-8601-date="2023-01-25"><day>25</day><month>01</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-01-25"><day>25</day><month>01</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Эко-Вектор</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2025-09-25"/></permissions><self-uri xlink:href="https://genescells.ru/2313-1829/article/view/133727">https://genescells.ru/2313-1829/article/view/133727</self-uri><abstract xml:lang="en"><p>This discussion article presents the theoretical background and results of our own histological study of the ampulla of the papilla of Vater in various animals to explain the absence of the gallbladder in some animals. In particular, the authors studied the structure of the duodenal mucosa in rats and rabbits. They suggest that the evolutionary loss of the gallbladder in some animals is associated with the need for rapid movement in space and high maneuverability. The realization of these properties may be hindered by a fluid-filled organ.</p></abstract><trans-abstract xml:lang="ru"><p>В настоящей дискуссионной статье представлены теоретические предпосылки и результаты собственного гистологического исследования ампулы фатерова сосочка у различных животных для объяснения факта отсутствия желчного пузыря у некоторых животных. В частности, авторы исследовали структуру слизистой оболочки 12-перстной кишки у крыс и кроликов. Высказано предположение о том, то эволюционная утрата желчного пузыря у ряда животных связана с необходимостью быстрого перемещения в пространстве и высокой маневренностью, реализации чего может препятствовать заполненный жидкостью орган.</p></trans-abstract><kwd-group xml:lang="en"><kwd>gallbladder</kwd><kwd>morphogenesis</kwd><kwd>histogenesis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>желчный пузырь</kwd><kwd>морфогенез</kwd><kwd>гистогенез</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Housset C., Chrétien Y., Debray D. et al. Functions of the Gallbladder. Compr. Physiol. 2016; 6(3): 1549–77.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Биологический энциклопедический словарь. 2-е изд. Москва: М.С. Гиляров; 1986. Советская Энциклопедия; 198. [Biological encyclopedic dictionary. 2nd ed. Moscow: M.S. Gilyarov; 1986. 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