Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute13367410.23868/202209002ReviewsНаучные обзорыReview ArticleComparison of histo- and organogenesis of human pancreas, white laboratory mouse and spiny mouse (Acomys)Сравнение гисто- и органогенеза поджелудочной железы человека, белой лабораторной мыши и иглистой мыши (Acomys)SultanovaK. N.СултановаК. Н.
Russian Federation
kasana555_07@mail.ruTitovaA. A.ТитоваА. А.
Russian Federation
kasana555_07@mail.ruPlushkinaA. S.ПлюшкинаА. С.
Russian Federation
kasana555_07@mail.ruAndreevaD. I.АндрееваД. И.
Russian Federation
kasana555_07@mail.ruKiyasovA. P.КиясовА. П.
Russian Federation
kasana555_07@mail.ruKazan (Volga region) Federal UniversityКазанский (Приволжский) федеральный университет2509202217214192401202324012023Copyright ©; 2022, Eco-VectorCopyright ©; 2022, Эко-Вектор2022Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/133674

The study of the embryonic development of the pancreas gives the opportunity to understand the mechanisms of organ regeneration in case of various pathologies. Worldwide research works, studying histo- and organogenesis of human pancreas, are based on data, received from model animals. Numerous processes of pancreatic development take several hours and remain unclear because white laboratory mouse has short gestation period. Spiny mouse (Acomys) has the prolonged prenatal period and can be a convenient model to study the stages of histo- and organogenesis of the pancreas. The review analyzed similarities and differences in the structure of human pancreas, white laboratory mouse and spiny mouse, the features of prenatal histo- and organogenesis of the pancreas, which should be considered in conducting and interpreting results of fundamental research, and possibility of using of spiny mice as a model animal to study embryonic development and pathology of the pancreas.

Изучение эмбрионального развития поджелудочной железы позволяет приблизить исследователя к ответам на ряд вопросов, связанных с механизмами регенерации органа при различных патологических состояниях. Во всем мире активно ведутся исследовательские работы по изучению гисто- и органогенеза поджелудочной железы человека, основываясь на данных, полученных на модельных животных. Многие процессы развития поджелудочной железы, протекающие несколько часов, остаются не ясными ввиду непродолжительного пренатального периода белой лабораторной мыши. Иглистые мыши (Acomys), имеющие более длительный гестационный период, являются удобной моделью для изучения этапов гисто- и органогенеза поджелудочной железы. Описаны сходства и различия строения поджелудочной железы человека, белой лабораторной мыши и мыши Acomys, особенности пренатального гисто- и органогенеза поджелудочной железы, которые следует учитывать при проведении и интерпретации результатов фундаментальных исследований, а также перспективность применения иглистых мышей в качестве модельных животных для изучения эмбрионального развития и патологии поджелудочной железы.

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