Genes & CellsGenes & Cells2313-18292500-2562Human Stem Cells Institute13366810.23868/gc133668Research ArticleThe problem of blood supply for large tissue-engineered bone grafts on the way to resolutionBozoI. Ya.info@eco-vector.com151220072415162401202324012023Copyright © 2007, Eco-Vector2007[Folkman J., Hochberg М. Self-regulation of growth in three dimensions. J. Exp. Med. 1973; 138: 745-53.][Polykandriotis E., Arkudas A., Horch R. et al. Autonomously vascularized cellular constructs in tissue engineering: opening a new perspective for biomedical science. J. Cell Mol. Med. 2007; 11(1): 6-20.][Arkudas A., Tjiawi J., Bleiziffer 0. et al. Fibrin gel-immobilized VEGF and bFGF efficiently stimulate Angiogenesis in the AV Loop Model. Mol. Med. 2007; 13(9-10): 480-7.][Ahrendt G, Chickening D., Ranieri J. Angiogenic growth factors: a review for tissue engineering. Tissue Eng. 1998; 2:117-30.][Khouri R., Upton J., Shaw W. Prefabrication of composite free flaps through staged microvascular transfer: an experimental and clinical study. Plast. Reconstr. Sung. 1991; 87: 108-15.][Lokmic Z., Stillaert F., Morrison W. et al. An arteriovenous loop in a protected space generates a permanent, highly vascular, tissue-engineered construct. FASEB J. 2007; 21(2): 511-22.][Arkudas A., Beier J., Heidner K. et al. Axial prevascularization of porous matrices by an arteriovenous loop promotes survival and differentiation of transplanted autologous osteoblasts. Tissue Eng. 2007; 13(7): 1549-60.][Kneser U., Polykandriotis E., Ohnolz J. et al. Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop. Tissue Eng. 2006; 12:1721-31.][Kuznetsov S.A., Robey P.G. A look at the history of bone marrow stromal cells. Graft. 2000; 3(6): 278-83.][Casabona F., Martin I., Muraglia A. et al. Prefabricated engineered bone flaps: an experimental model of tissue reconstruction in plastic surgery. Plast Reconstr Surg. 1998; 101(3): 577-81.]