Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12514710.23868/gc125147ReviewsНаучные обзорыReview ArticleTransplantation of two HLA-compatible umbilical cord blood units as a modern approach to solving the problem of a small number of cells and an alternative to allogeneic bone marrow transplantation in leukemia in adult patientsТрансплантация двух HLA-совместимых единиц пуповинной крови как современный подход к решению проблемы малого количества клеток и альтернатива аллогенной трансплантации костного мозга при лейкемии у взрослых пациентовBersenevA. V.БерсеневА. В.
United States
redaktor@celltranspl.ruThomas Jefferson UniversityУниверситет Томаса Джефферсонаru150120062006149511801202318012023Received:18012023Accepted:18012023Published:15012006Copyright ©; 2023, Eco-VectorCopyright ©; 2023, Эко-Вектор2023Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/125147

Umbilical cord blood cell transplantation [PC], as an alternative to unrelated bone marrow transplantation [TCM], has already firmly taken its place in oncohematology. The main advantages of PC transplantation, in comparison with TCM, include a lower incidence of the "graft-versus-host reaction" [GVHD] and a more liberal approach to the degree of HLA compatibility of the graft with an equal post-transplant prognosis, however, with PC transplantation, a lower engraftment and an increased likelihood of recurrence are noted [1,2].

Трансплантация клеток пуповинной крови [ПК], как альтернатива неродственной трансплантации костного мозга [ТКМ], уже прочно заняла свои позиции в онкогематологии. К основным преимуществам трансплантации ПК, по сравнению с ТКМ, относят более низкую частоту развития «реакции трансплантат-против-хозяина» [РТПХ] и более либеральный подход к степени HLA-совместимости трансплантата при равном посттрансплантационном прогнозе, однако, при трансплантации ПК отмечают более низкий engraftment и повышенную вероятность рецидива [1,2].

Румянцев А.Г., Масчан А.А. Трансплантация гемопоэтических стволовых клеток у детей. - М„ 2003, 921.Rocha V., Sanz G., Gluckman E. Eurocord and European Blood and Marrow Transplant Group. Umbilical cord blood transplantation. Curr. Opin. Hematol. 2004; 11[6): 375-85.Wagner J.E., Barker J.N., DeFor T.E. et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002; 100:1611-8.Ohwada C., Nakaseko C., Ozawa S. et al. Second cord blood transplantation [CBT) with reduced-intensity conditioning for graft failure after the first CBT for AML. Bone Marrow Transplant. 2004; 34(11): 999-1000.Wolff S. Second hematopoietic stem cell transplantation forthe treatment of graft failure, graft rejection of relapse after allogenic transplantation. Bone Marrow Transplant. 2002; 29: 545-52.Tanaka T., Matsubara H., Adachi S. et al. Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation. Int. J. Hematol. 2004; 80(5): 467-9.Mathe G., Amiel J.L., Schwarzenberg L. étal. Bone marrowtransplantation in man. Transplant. Proc. 1969; 1:16-24.Kogler G., Nurnberger W„ Fischer J. et al. Simultaneous cord blood transplantation of ex vivo expanded together with non-expanded cells for high risk leukemia. Bone Marrow Transplant. 1999; 24[4): 397-403.Pecora A.L., Stiff P., Jennis A. et al. Prompt and durable engraftment in two older adult patients with high risk chronic myelogenous leukemia [CML) using exvivo expanded and unmanipulated unrelated umbilical cord blood. Bone Marrow Transplant. 2000; 25: 797-9.Fernandez M.N., Regidor C., Cabrera R. et al. Unrelated umbilical cord blood transplants in adults: Early recovery of neutrophils by supportive cotransplantation of a low number of highly purified peripheral blood CD34+ cells from an HLA-haploidentical donor. Exp. Hematol. 2003; 31(6): 535-44.Ende М. Lymphangiosarcoma. Report of a case. Рас. Med. Surg. 1966; 74[2): 80-2.Ende M. Hematopoietic transplantation by means of fetal [cord) blood. A new method. Va. Med. Mon. 1972; 99(3): 276-80.Shen B.J., Hou H.S., Zhang H.Q., Sul X.W. Unrelated, HLA-mismatched multiple human umbilical cord blood transfusion in four cases with advanced solid tumors: initial studies. Blood Cells 1994; 20: 285-92.Barker J.N., Weisdorf D.J., Wagner J.E. Creation of a double chimera after the transplantation of umbilical-cord blood from two partially matched unrelated donors. N. Engl. J. Med. 2001; 344:1870-1.Barker J.N., Weisdorf D.J., DeForT.E. et al. Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced intensity conditioning. Blood 2003; 102: 1915-19.Barker J.N., Weisdorf D.J., DeForT.E. et al. Multiple unit unrelated donor umbilical cord blood transplantation in high risk adults with hematologic malignancies: impact on engraftment and chimerism. Blood 2002; 100: 41a.Zanjani E., Almeida-Porada G., Hangoc G., Broxmeyer H.E. Enhanced short term engraftment of human cells in sheep transplanted with multiple cord bloods: implications for transplantation of adults. Blood 2000; 96: 552a [abstract).Kim D.W., Chung Y.J., Kim T.G. et al. Cotransplantation third-party mesenchymal stromal cells can alleviate single-donor predominance and increase engraftment from double cord transplantation. Blood 2004; 103:1941-8.Yahata T., Ando K., Miyatake H. et al. Competitive repopulation assay of two gene-marked cord blood units in N0D/SCID/gammac[null) mice. Mol. Ther. 2004; 10[5): 882-91.De Lima M„ St John L.S., Wieder E.D. et al. Double-chimaerism after transplantation of two human leucocyte antigen mismatched, unrelated cord blood units. Br. J. Haematol. 2002; 119: 773-6.Barker J.N., Weisdorf D.J., DeForT.E. et al. Transplantation of two partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005; 105[3):1343-7.Barker J. Double cord blood transplants in adult recipients. 7th Int Congress Cell Transplant Society. Nov. 17-20, Boston, USA. Book of abstracts; abs. 236; 59.Barker J.N., DeFor T„ Davies S.M. etal. Impact of multiple unit unrelated donor umbilical cord blood transplantation in adults: preliminary analysis of safety and efficacy. Blood 2004; 98: 666a.Nauta A.J., Kruisselbrink A.B., Lurvink E. et al. Enhanced engraftment of umbilical cord blood-derived stem cells in NOD/SCID mice by cotransplantation of a second unrelated cord blood unit. Exp. Hematol. 2005; 33[10): 1249-56.Hung G.Y., Chiou T.J., Chang C.Y. et al. Double-unit unrelated cord blood transplantation for chronic myelogenous leukemia. Int. J. Hematol. 2005; 82[2): 159-61.Wang F.R., Huang X.J., Zhang Y.C. et al. Successful transplantation of double unit umbilical-cord blood from unrelated donors in high risk leukemia with a long follow-up. Chin. Med. J. 2005; 118[9): 772-6.