Genes & CellsGenes & Cells2313-18292500-2562Human Stem Cells Institute12240210.23868/gc122402Review ArticleCell technologies in the treatmemt of critical lower limbs ischemiaSmolyaninovA. B.info@eco-vector.comPykhtinE. V.info@eco-vector.comBulginD. V.info@eco-vector.comTomonagaM.info@eco-vector.comCenter of Cell and Gene Therapy, Stem cell Bank «POKROVSKI»Nagasaki University150920072340461601202316012023Copyright © 2007, Eco-Vector2007<p>This article presents reviews application of cell technologies in the treatment of critical limb ischemia. Surgery treatment remains a basic method in the treatment of vascular obliterans limb diseases. In our days surgical methods are known as the most effective treatment of main artery atherosclerosis, but this kind of treatment is not so good for treatment peripheral arterial diseases such as thromboangitis obliterans (Buergers disease) because of often restenosis and rethrombosis development. Principal purpose efforts of surgeons according on ensuring of adequate blood flow in terminal parts of limb and also on support effective perfusion of tissue. This aim could be obtain due to undirected revascularization. Recently thanks to development of cells technologies on a level with osteothrepanation and lumbal sympathectomy it became possible to create new ways of roundabout blood flow in ischemic limb. Autological stem cells transplantation to patients with critical ischemic limb provides an appearance of new sites revascularization. In last years experimental and clinical studies in this area confirm safety and efficiency of the stem cells transplantation to patients with ischemic limb disease. 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