Genes & CellsGenes & Cells2313-18292500-2562Human Stem Cells Institute12228210.23868/gc122282Research ArticleRegulation of progenitor cell homing to the area of myocardial infarction by prolonged secretion of SDF-1 factorMelikhovaV. S.info@eco-vector.com150920072321221601202316012023Copyright © 2007, Eco-Vector2007[Vandervelde S., Van Luyn M.J., Tio R.A., et al. Signaling factors in stem cell- mediated repair of infracted myocardium. J. Mol. Cell Cardiol. 2005; 39: 363-76.][De Falco E., Porcelli D., Torella A.R., et al. SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells. Blood. 2004; 104: 3472-82.][Blades M.C., Manzo A., Ingegnoli F., et al. Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice. J. Immunol. 2002; 168: 4308-17.][Hattori K., Heissig B., Rafii S. The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1. Leuk. Lymphoma 2003; 44: 575-82.][Gazitt Y. Homing and mobilization of hematopoietic stem cells and hematopoietic cancer cells are mirror image processes, utilizing similar signaling pathways and occurring concurrently: circulating cancer cells constitute an ideal target for concurrent treatment with chemotherapy and antilineagespecific antibodies. Leukemia. 2004; 18: 1-10.][Ma J., Ge J., Zhang S., et al. Time course of myocardial stromal cell-derived factor 1 expression and beneficial effects of intravenously administered bone marrow stem cells in rats with experimental myocardial infarction. Basic Res. Cardiol. 2005; 100: 217-23.][Abbott J.D., Huang Y., Liu D., et al. Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce еhoming in the absence of injury. Circulation. 2004; 110: 3300-5.][Eltrami A.P., Barlucchi L., Torella D., et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003; 114: 763-76.]