Genes & CellsGenes & CellsГены и КлеткиGenes and Cells2313-18292500-2562Human Stem Cells Institute12219710.23868/201903001ArticlesСтатьиResearch ArticleGene-activated hydrogels in regenerative medicineГен-активированные гидрогели в регенеративной медицинеBozoI. YБозоИ. Яbozo.ilya@gmail.comBilyalovA. IБиляловА. ИMavlikeevM. OМавликеевМ. ОDeevR. VДеевР. ВResearch Institute of General Pathology and PathophysiologyНаучно-исследовательский институт общей патологии и патофизиологииA.I. Burnazyana Federal Medical Biophysical Center, FMBA of RussiaФедеральный медицинский биофизический центр им. А.И. Бурназяна ФМБА РоссииHistograft, LLCООО «Гистографт»Kazan (Volga Region] Federal UniversityКазанский (Приволжский) федеральный университетКазанский (Приволжский) федеральный университетI.P. Pavlov Ryazan State Medical UniversityInstitute of Human Stem Cells, PJSCРязанский государственный медицинский университет им. И.П. ПавловаПАО «Институт Стволовых Клеток Человека»15032019141VOL 14, NO1 (2019)ТОМ 14, №1 (2019)162116012023Copyright ©; 2019, Eco-VectorCopyright ©; 2019, Эко-Вектор2019Eco-VectorЭко-Векторhttps://genescells.ru/2313-1829/article/view/122197

Hydrogels capable to optimize reparative regeneration and delivere biologically active components (drugs, cells, growth factors, gene constructs) in the implantation area are attracting increasing attention of developers due to high potential effectiveness of these medical devices and compliance of the approach with well-known medical trend - minimally invasive technologies. Hydrogels containing gene constructs have become especially relevant for clinical practice in the territory of the Eurasian Customs Union after gen-therapeutic drug and the first gene-activated bone substitute were registered in Russia. This review describes the main directions in development of gene-activated hydrogels divided into two categories: primitive and optimized ("smart”-hydrogels). In the case hydrogel scaffolds provide passive delivery of gene constructs, while the latter facilitate gene constructs to realize their mechanism of action.

Гидрогели, способные оптимизировать репаративную регенерацию тканей и доставить в зону имплантации биологически активные компоненты (лекарственные средства, клетки, факторы роста, генные конструкции) привлекают все большее внимание разработчиков в связи с высокой потенциальной эффективность таких изделий и соответствие этого подхода известному тренду медицины - развитию малоинвазивных технологий. Гидрогели, содержащие генные конструкции, стали особенно актуальны для клинической практики на территории Евразийского союза после регистрации в России геннотерапевтического препарата и первого ген-активированного остеопластического материала. В данном обзоре описаны основные направления в разработке ген-активированных гелей, разделенных на две категории: простые и оптимизированные («smart»-гидрогели). В первом случае гидрогелевый матрикс-носитель осуществляет пассивную доставку генных конструкций, тогда как вторые оказывают положительное влияние на реализацию генными конструкциями основного механизма действия.

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